Quantitative sequencing using BID-seq uncovers abundant pseudouridines in mammalian mRNA at base resolution

Functional characterization of pseudouridine (Ψ) in mammalian mRNA has been hampered by the lack of a quantitative method that maps Ψ in the whole transcriptome. We report bisulfite-induced deletion sequencing (BID-seq), which uses a bisulfite-mediated reaction to convert pseudouridine stoichiometri...

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Detalles Bibliográficos
Autores principales: Dai, Qing, Zhang, Li-Sheng, Sun, Hui-Lung, Pajdzik, Kinga, Yang, Lei, Ye, Chang, Ju, Cheng-Wei, Liu, Shun, Wang, Yuru, Zheng, Zhong, Zhang, Linda, Harada, Bryan T., Dou, Xiaoyang, Irkliyenko, Iryna, Feng, Xinran, Zhang, Wen, Pan, Tao, He, Chuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017504/
https://www.ncbi.nlm.nih.gov/pubmed/36302989
http://dx.doi.org/10.1038/s41587-022-01505-w

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