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Precision mitochondrial DNA editing with high-fidelity DddA-derived base editors

Bacterial toxin DddA-derived cytosine base editors (DdCBEs)—composed of split DddA(tox) (a cytosine deaminase specific to double-stranded DNA), custom-designed TALE (transcription activator-like effector) DNA-binding proteins, and a uracil glycosylase inhibitor—enable mitochondrial DNA (mtDNA) editi...

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Detalles Bibliográficos
Autores principales:	Lee, Seonghyun, Lee, Hyunji, Baek, Gayoung, Kim, Jin-Soo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group US 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017512/ https://www.ncbi.nlm.nih.gov/pubmed/36229610 http://dx.doi.org/10.1038/s41587-022-01486-w

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