Fumarate induces vesicular release of mtDNA to drive innate immunity

Mutations in fumarate hydratase (FH) cause hereditary leiomyomatosis and renal cell carcinoma(1). Loss of FH in the kidney elicits several oncogenic signalling cascades through the accumulation of the oncometabolite fumarate(2). However, although the long-term consequences of FH loss have been descr...

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Detalles Bibliográficos
Autores principales: Zecchini, Vincent, Paupe, Vincent, Herranz-Montoya, Irene, Janssen, Joëlle, Wortel, Inge M. N., Morris, Jordan L., Ferguson, Ashley, Chowdury, Suvagata Roy, Segarra-Mondejar, Marc, Costa, Ana S. H., Pereira, Gonçalo C., Tronci, Laura, Young, Timothy, Nikitopoulou, Efterpi, Yang, Ming, Bihary, Dóra, Caicci, Federico, Nagashima, Shun, Speed, Alyson, Bokea, Kalliopi, Baig, Zara, Samarajiwa, Shamith, Tran, Maxine, Mitchell, Thomas, Johnson, Mark, Prudent, Julien, Frezza, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017517/
https://www.ncbi.nlm.nih.gov/pubmed/36890229
http://dx.doi.org/10.1038/s41586-023-05770-w

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