A rare human variant that disrupts GPR10 signalling causes weight gain in mice

Disruption of brain-expressed G protein-coupled receptor-10 (GPR10) causes obesity in animals. Here, we identify multiple rare variants in GPR10 in people with severe obesity and in normal weight controls. These variants impair ligand binding and G protein-dependent signalling in cells. Transgenic m...

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Detalles Bibliográficos
Autores principales: Talbot, Fleur, Feetham, Claire H., Mokrosiński, Jacek, Lawler, Katherine, Keogh, Julia M., Henning, Elana, Mendes de Oliveira, Edson, Ayinampudi, Vikram, Saeed, Sadia, Bonnefond, Amélie, Arslan, Mohammed, Yeo, Giles S. H., Froguel, Philippe, Bechtold, David A., Adamson, Antony, Humphreys, Neil, Barroso, Inês, Luckman, Simon M., Farooqi, I. Sadaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017677/
https://www.ncbi.nlm.nih.gov/pubmed/36922513
http://dx.doi.org/10.1038/s41467-023-36966-3

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