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The first detection of two Aeromonas strains in mice of the genus Apodemus
Aeromonas spp. are gram-negative facultatively anaerobic bacilli recovered mainly from aquatic environments. Aeromonas spp. were reported to be associated with infections primarily in aquatic and to a lesser extent in terrestrial animals as well as in humans. Up-to-date little is known about aeromon...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017686/ https://www.ncbi.nlm.nih.gov/pubmed/36922567 http://dx.doi.org/10.1038/s41598-023-31306-3 |
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author | Andriyanov, Pavel A. Kashina, Daria D. Liskova, Elena A. Zhurilov, Pavel A. Tutrina, Anastasia I. Ermolaeva, Svetlana A. Zakharova, Olga I. Blokhin, Andrey A. |
author_facet | Andriyanov, Pavel A. Kashina, Daria D. Liskova, Elena A. Zhurilov, Pavel A. Tutrina, Anastasia I. Ermolaeva, Svetlana A. Zakharova, Olga I. Blokhin, Andrey A. |
author_sort | Andriyanov, Pavel A. |
collection | PubMed |
description | Aeromonas spp. are gram-negative facultatively anaerobic bacilli recovered mainly from aquatic environments. Aeromonas spp. were reported to be associated with infections primarily in aquatic and to a lesser extent in terrestrial animals as well as in humans. Up-to-date little is known about aeromonads associated with wild animals, especially with rodents. This study reported the first isolation and characterization of two Aeromonas spp. from internal organs of apparently healthy wild rodents Apodemus uralensis and Apodemus flavicollis captured in the wild environment in the European part of Russia. Isolates were identified as A. hydrophila M-30 and A. encheleia M-2 using the multilocus sequence analysis (MLSA) approach. The isolation of the A. encheleia from rodents is the first described case. Both strains demonstrated beta-hemolytic activity towards human erythrocytes. Antimicrobial susceptibility testing showed that both Aeromonas strains were resistant and intermediate to carbapenems and piperacillin-tazobactam, which was caused by the expression of the genus-specific CphA carbapenemases. A. hydrophila M-30 also demonstrated trimethoprim resistant phenotype. This is usually caused by the carriage of the dfrA or dfrB genes in aeromonads which are frequently associated with integron class I. The latter however was absent in both isolates. Our results expand our understanding of possible aeromonad reservoirs and demonstrate the likelihood of the formation of natural foci of Aeromonas infection and a new link in the chain of the spread of antimicrobial resistance as well. |
format | Online Article Text |
id | pubmed-10017686 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-100176862023-03-17 The first detection of two Aeromonas strains in mice of the genus Apodemus Andriyanov, Pavel A. Kashina, Daria D. Liskova, Elena A. Zhurilov, Pavel A. Tutrina, Anastasia I. Ermolaeva, Svetlana A. Zakharova, Olga I. Blokhin, Andrey A. Sci Rep Article Aeromonas spp. are gram-negative facultatively anaerobic bacilli recovered mainly from aquatic environments. Aeromonas spp. were reported to be associated with infections primarily in aquatic and to a lesser extent in terrestrial animals as well as in humans. Up-to-date little is known about aeromonads associated with wild animals, especially with rodents. This study reported the first isolation and characterization of two Aeromonas spp. from internal organs of apparently healthy wild rodents Apodemus uralensis and Apodemus flavicollis captured in the wild environment in the European part of Russia. Isolates were identified as A. hydrophila M-30 and A. encheleia M-2 using the multilocus sequence analysis (MLSA) approach. The isolation of the A. encheleia from rodents is the first described case. Both strains demonstrated beta-hemolytic activity towards human erythrocytes. Antimicrobial susceptibility testing showed that both Aeromonas strains were resistant and intermediate to carbapenems and piperacillin-tazobactam, which was caused by the expression of the genus-specific CphA carbapenemases. A. hydrophila M-30 also demonstrated trimethoprim resistant phenotype. This is usually caused by the carriage of the dfrA or dfrB genes in aeromonads which are frequently associated with integron class I. The latter however was absent in both isolates. Our results expand our understanding of possible aeromonad reservoirs and demonstrate the likelihood of the formation of natural foci of Aeromonas infection and a new link in the chain of the spread of antimicrobial resistance as well. Nature Publishing Group UK 2023-03-15 /pmc/articles/PMC10017686/ /pubmed/36922567 http://dx.doi.org/10.1038/s41598-023-31306-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Andriyanov, Pavel A. Kashina, Daria D. Liskova, Elena A. Zhurilov, Pavel A. Tutrina, Anastasia I. Ermolaeva, Svetlana A. Zakharova, Olga I. Blokhin, Andrey A. The first detection of two Aeromonas strains in mice of the genus Apodemus |
title | The first detection of two Aeromonas strains in mice of the genus Apodemus |
title_full | The first detection of two Aeromonas strains in mice of the genus Apodemus |
title_fullStr | The first detection of two Aeromonas strains in mice of the genus Apodemus |
title_full_unstemmed | The first detection of two Aeromonas strains in mice of the genus Apodemus |
title_short | The first detection of two Aeromonas strains in mice of the genus Apodemus |
title_sort | first detection of two aeromonas strains in mice of the genus apodemus |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017686/ https://www.ncbi.nlm.nih.gov/pubmed/36922567 http://dx.doi.org/10.1038/s41598-023-31306-3 |
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