The SMARCA4(R1157W) mutation facilitates chromatin remodeling and confers PRMT1/SMARCA4 inhibitors sensitivity in colorectal cancer

Genomic studies have demonstrated a high frequency of genetic alterations in components of the SWI/SNF complex including the core subunit SMARCA4. However, the mechanisms of tumorigenesis driven by SMARCA4 mutations, particularly in colorectal cancer (CRC), remain largely unknown. In this study, we...

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Detalles Bibliográficos
Autores principales: Zeng, Xiangwei, Yao, Bing, Liu, Jianpeng, Gong, Guan-Wen, Liu, Ming, Li, Jiahuang, Pan, Hua-Feng, Li, Qixiang, Yang, Dongjun, Lu, Peifen, Wu, Dongliang, Xu, Peipei, Chen, Bing, Chen, Panhai, Zhang, Ming, Zen, Ke, Jing, Jian, Huang, David C. S., Chen, Dijun, Jiang, Zhi-Wei, Zhao, Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017700/
https://www.ncbi.nlm.nih.gov/pubmed/36922568
http://dx.doi.org/10.1038/s41698-023-00367-y

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