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The molecular characteristics, diagnosis, and treatment of macrolide-resistant Mycoplasma pneumoniae in children

The purpose of this study is to review the molecular characteristics, the diagnosis, and treatment of the widespread infection of macrolide-resistant Mycoplasma pneumoniae (M. pneumoniae; MRMP) in children, thus providing a better knowledge of this infection and presenting the associated problems. S...

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Autores principales: Leng, Maodong, Yang, Junmei, Zhou, Juanjuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017863/
https://www.ncbi.nlm.nih.gov/pubmed/36937963
http://dx.doi.org/10.3389/fped.2023.1115009
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author Leng, Maodong
Yang, Junmei
Zhou, Juanjuan
author_facet Leng, Maodong
Yang, Junmei
Zhou, Juanjuan
author_sort Leng, Maodong
collection PubMed
description The purpose of this study is to review the molecular characteristics, the diagnosis, and treatment of the widespread infection of macrolide-resistant Mycoplasma pneumoniae (M. pneumoniae; MRMP) in children, thus providing a better knowledge of this infection and presenting the associated problems. Single point mutations in the V region of the 23S rRNA gene of M. pneumoniae genome are associated with macrolide resistance. P1–1, MLVA4-5-7-2, and ST3 are usually the predominated genetic types in the M. pneumoniae epidemics. The short-term two times serological IgM (or together with IgG) test in the acute stage can be used for confirmation. Combined serological testing and PCR might be a more prudent method to reduce macrolide consumption and antibiotic selective pressure in a clinical setting. Molecular methods for the detection of single-nucleotide mutations in the V region of the 23S rRNA gene can be used for the diagnosis of MRMP. The routine use of macrolide for the treatment of macrolide-sensitive Mycoplasma pneumoniae (MSMP) infections can get good effect, but the effects are limited for severe MRMP infections. Additional corticosteroids may be required for the treatment of severe MRMP infections in children in China during the era of MRMP.
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spelling pubmed-100178632023-03-17 The molecular characteristics, diagnosis, and treatment of macrolide-resistant Mycoplasma pneumoniae in children Leng, Maodong Yang, Junmei Zhou, Juanjuan Front Pediatr Pediatrics The purpose of this study is to review the molecular characteristics, the diagnosis, and treatment of the widespread infection of macrolide-resistant Mycoplasma pneumoniae (M. pneumoniae; MRMP) in children, thus providing a better knowledge of this infection and presenting the associated problems. Single point mutations in the V region of the 23S rRNA gene of M. pneumoniae genome are associated with macrolide resistance. P1–1, MLVA4-5-7-2, and ST3 are usually the predominated genetic types in the M. pneumoniae epidemics. The short-term two times serological IgM (or together with IgG) test in the acute stage can be used for confirmation. Combined serological testing and PCR might be a more prudent method to reduce macrolide consumption and antibiotic selective pressure in a clinical setting. Molecular methods for the detection of single-nucleotide mutations in the V region of the 23S rRNA gene can be used for the diagnosis of MRMP. The routine use of macrolide for the treatment of macrolide-sensitive Mycoplasma pneumoniae (MSMP) infections can get good effect, but the effects are limited for severe MRMP infections. Additional corticosteroids may be required for the treatment of severe MRMP infections in children in China during the era of MRMP. Frontiers Media S.A. 2023-03-02 /pmc/articles/PMC10017863/ /pubmed/36937963 http://dx.doi.org/10.3389/fped.2023.1115009 Text en © 2023 Leng, Yang and Zhou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Leng, Maodong
Yang, Junmei
Zhou, Juanjuan
The molecular characteristics, diagnosis, and treatment of macrolide-resistant Mycoplasma pneumoniae in children
title The molecular characteristics, diagnosis, and treatment of macrolide-resistant Mycoplasma pneumoniae in children
title_full The molecular characteristics, diagnosis, and treatment of macrolide-resistant Mycoplasma pneumoniae in children
title_fullStr The molecular characteristics, diagnosis, and treatment of macrolide-resistant Mycoplasma pneumoniae in children
title_full_unstemmed The molecular characteristics, diagnosis, and treatment of macrolide-resistant Mycoplasma pneumoniae in children
title_short The molecular characteristics, diagnosis, and treatment of macrolide-resistant Mycoplasma pneumoniae in children
title_sort molecular characteristics, diagnosis, and treatment of macrolide-resistant mycoplasma pneumoniae in children
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017863/
https://www.ncbi.nlm.nih.gov/pubmed/36937963
http://dx.doi.org/10.3389/fped.2023.1115009
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