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Regulatory roles of ferroptosis-related non-coding RNAs and their research progress in urological malignancies

Ferroptosis is a new type of cell death characterized by damage to the intracellular microenvironment, which causes the accumulation of lipid hydroperoxide and reactive oxygen species to cause cytotoxicity and regulated cell death. Non-coding RNAs (ncRNAs) play an important role in gene expression a...

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Autores principales: Wang, Shijin, Jiang, Bowen, Xie, Deqian, Li, Xiunan, Wu, Guangzhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017998/
https://www.ncbi.nlm.nih.gov/pubmed/36936418
http://dx.doi.org/10.3389/fgene.2023.1133020
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author Wang, Shijin
Jiang, Bowen
Xie, Deqian
Li, Xiunan
Wu, Guangzhen
author_facet Wang, Shijin
Jiang, Bowen
Xie, Deqian
Li, Xiunan
Wu, Guangzhen
author_sort Wang, Shijin
collection PubMed
description Ferroptosis is a new type of cell death characterized by damage to the intracellular microenvironment, which causes the accumulation of lipid hydroperoxide and reactive oxygen species to cause cytotoxicity and regulated cell death. Non-coding RNAs (ncRNAs) play an important role in gene expression at the epigenetic, transcriptional, and post-transcriptional levels through interactions with different DNAs, RNAs, or proteins. Increasing evidence has shown that ferroptosis-related ncRNAs are closely related to the occurrence and progression of several diseases, including urological malignancies. Recently, the role of ferroptosis-associated ncRNAs (long non-coding RNAs, micro RNAs, and circular RNAs) in the occurrence, drug resistance, and prognosis of urological malignancies has attracted widespread attention. However, this has not yet been addressed systematically. In this review, we discuss this issue as much as possible to expand the knowledge and understanding of urological malignancies to provide new ideas for exploring the diagnosis and treatment of urological malignancies in the future. Furthermore, we propose some challenges in the clinical application of ferroptosis-associated ncRNAs.
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spelling pubmed-100179982023-03-17 Regulatory roles of ferroptosis-related non-coding RNAs and their research progress in urological malignancies Wang, Shijin Jiang, Bowen Xie, Deqian Li, Xiunan Wu, Guangzhen Front Genet Genetics Ferroptosis is a new type of cell death characterized by damage to the intracellular microenvironment, which causes the accumulation of lipid hydroperoxide and reactive oxygen species to cause cytotoxicity and regulated cell death. Non-coding RNAs (ncRNAs) play an important role in gene expression at the epigenetic, transcriptional, and post-transcriptional levels through interactions with different DNAs, RNAs, or proteins. Increasing evidence has shown that ferroptosis-related ncRNAs are closely related to the occurrence and progression of several diseases, including urological malignancies. Recently, the role of ferroptosis-associated ncRNAs (long non-coding RNAs, micro RNAs, and circular RNAs) in the occurrence, drug resistance, and prognosis of urological malignancies has attracted widespread attention. However, this has not yet been addressed systematically. In this review, we discuss this issue as much as possible to expand the knowledge and understanding of urological malignancies to provide new ideas for exploring the diagnosis and treatment of urological malignancies in the future. Furthermore, we propose some challenges in the clinical application of ferroptosis-associated ncRNAs. Frontiers Media S.A. 2023-03-02 /pmc/articles/PMC10017998/ /pubmed/36936418 http://dx.doi.org/10.3389/fgene.2023.1133020 Text en Copyright © 2023 Wang, Jiang, Xie, Li and Wu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Wang, Shijin
Jiang, Bowen
Xie, Deqian
Li, Xiunan
Wu, Guangzhen
Regulatory roles of ferroptosis-related non-coding RNAs and their research progress in urological malignancies
title Regulatory roles of ferroptosis-related non-coding RNAs and their research progress in urological malignancies
title_full Regulatory roles of ferroptosis-related non-coding RNAs and their research progress in urological malignancies
title_fullStr Regulatory roles of ferroptosis-related non-coding RNAs and their research progress in urological malignancies
title_full_unstemmed Regulatory roles of ferroptosis-related non-coding RNAs and their research progress in urological malignancies
title_short Regulatory roles of ferroptosis-related non-coding RNAs and their research progress in urological malignancies
title_sort regulatory roles of ferroptosis-related non-coding rnas and their research progress in urological malignancies
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017998/
https://www.ncbi.nlm.nih.gov/pubmed/36936418
http://dx.doi.org/10.3389/fgene.2023.1133020
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