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Overview of the SARS-CoV-2 genotypes circulating in Latin America during 2021
Latin America is one of the regions in which the COVID-19 pandemic has a stronger impact, with more than 72 million reported infections and 1.6 million deaths until June 2022. Since this region is ecologically diverse and is affected by enormous social inequalities, efforts to identify genomic patte...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018007/ https://www.ncbi.nlm.nih.gov/pubmed/36935725 http://dx.doi.org/10.3389/fpubh.2023.1095202 |
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author | Molina-Mora, Jose Arturo Reales-González, Jhonnatan Camacho, Erwin Duarte-Martínez, Francisco Tsukayama, Pablo Soto-Garita, Claudio Brenes, Hebleen Cordero-Laurent, Estela Ribeiro dos Santos, Andrea Guedes Salgado, Cláudio Santos Silva, Caio Santana de Souza, Jorge Nunes, Gisele Negri, Tatianne Vidal, Amanda Oliveira, Renato Oliveira, Guilherme Muñoz-Medina, José Esteban Salas-Lais, Angel Gustavo Mireles-Rivera, Guadalupe Sosa, Ezequiel Turjanski, Adrián Monzani, María Cecilia Carobene, Mauricio G. Remes Lenicov, Federico Schottlender, Gustavo Fernández Do Porto, Darío A. Kreuze, Jan Frederik Sacristán, Luisa Guevara-Suarez, Marcela Cristancho, Marco Campos-Sánchez, Rebeca Herrera-Estrella, Alfredo |
author_facet | Molina-Mora, Jose Arturo Reales-González, Jhonnatan Camacho, Erwin Duarte-Martínez, Francisco Tsukayama, Pablo Soto-Garita, Claudio Brenes, Hebleen Cordero-Laurent, Estela Ribeiro dos Santos, Andrea Guedes Salgado, Cláudio Santos Silva, Caio Santana de Souza, Jorge Nunes, Gisele Negri, Tatianne Vidal, Amanda Oliveira, Renato Oliveira, Guilherme Muñoz-Medina, José Esteban Salas-Lais, Angel Gustavo Mireles-Rivera, Guadalupe Sosa, Ezequiel Turjanski, Adrián Monzani, María Cecilia Carobene, Mauricio G. Remes Lenicov, Federico Schottlender, Gustavo Fernández Do Porto, Darío A. Kreuze, Jan Frederik Sacristán, Luisa Guevara-Suarez, Marcela Cristancho, Marco Campos-Sánchez, Rebeca Herrera-Estrella, Alfredo |
author_sort | Molina-Mora, Jose Arturo |
collection | PubMed |
description | Latin America is one of the regions in which the COVID-19 pandemic has a stronger impact, with more than 72 million reported infections and 1.6 million deaths until June 2022. Since this region is ecologically diverse and is affected by enormous social inequalities, efforts to identify genomic patterns of the circulating SARS-CoV-2 genotypes are necessary for the suitable management of the pandemic. To contribute to the genomic surveillance of the SARS-CoV-2 in Latin America, we extended the number of SARS-CoV-2 genomes available from the region by sequencing and analyzing the viral genome from COVID-19 patients from seven countries (Argentina, Brazil, Costa Rica, Colombia, Mexico, Bolivia, and Peru). Subsequently, we analyzed the genomes circulating mainly during 2021 including records from GISAID database from Latin America. A total of 1,534 genome sequences were generated from seven countries, demonstrating the laboratory and bioinformatics capabilities for genomic surveillance of pathogens that have been developed locally. For Latin America, patterns regarding several variants associated with multiple re-introductions, a relatively low percentage of sequenced samples, as well as an increment in the mutation frequency since the beginning of the pandemic, are in line with worldwide data. Besides, some variants of concern (VOC) and variants of interest (VOI) such as Gamma, Mu and Lambda, and at least 83 other lineages have predominated locally with a country-specific enrichments. This work has contributed to the understanding of the dynamics of the pandemic in Latin America as part of the local and international efforts to achieve timely genomic surveillance of SARS-CoV-2. |
format | Online Article Text |
id | pubmed-10018007 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100180072023-03-17 Overview of the SARS-CoV-2 genotypes circulating in Latin America during 2021 Molina-Mora, Jose Arturo Reales-González, Jhonnatan Camacho, Erwin Duarte-Martínez, Francisco Tsukayama, Pablo Soto-Garita, Claudio Brenes, Hebleen Cordero-Laurent, Estela Ribeiro dos Santos, Andrea Guedes Salgado, Cláudio Santos Silva, Caio Santana de Souza, Jorge Nunes, Gisele Negri, Tatianne Vidal, Amanda Oliveira, Renato Oliveira, Guilherme Muñoz-Medina, José Esteban Salas-Lais, Angel Gustavo Mireles-Rivera, Guadalupe Sosa, Ezequiel Turjanski, Adrián Monzani, María Cecilia Carobene, Mauricio G. Remes Lenicov, Federico Schottlender, Gustavo Fernández Do Porto, Darío A. Kreuze, Jan Frederik Sacristán, Luisa Guevara-Suarez, Marcela Cristancho, Marco Campos-Sánchez, Rebeca Herrera-Estrella, Alfredo Front Public Health Public Health Latin America is one of the regions in which the COVID-19 pandemic has a stronger impact, with more than 72 million reported infections and 1.6 million deaths until June 2022. Since this region is ecologically diverse and is affected by enormous social inequalities, efforts to identify genomic patterns of the circulating SARS-CoV-2 genotypes are necessary for the suitable management of the pandemic. To contribute to the genomic surveillance of the SARS-CoV-2 in Latin America, we extended the number of SARS-CoV-2 genomes available from the region by sequencing and analyzing the viral genome from COVID-19 patients from seven countries (Argentina, Brazil, Costa Rica, Colombia, Mexico, Bolivia, and Peru). Subsequently, we analyzed the genomes circulating mainly during 2021 including records from GISAID database from Latin America. A total of 1,534 genome sequences were generated from seven countries, demonstrating the laboratory and bioinformatics capabilities for genomic surveillance of pathogens that have been developed locally. For Latin America, patterns regarding several variants associated with multiple re-introductions, a relatively low percentage of sequenced samples, as well as an increment in the mutation frequency since the beginning of the pandemic, are in line with worldwide data. Besides, some variants of concern (VOC) and variants of interest (VOI) such as Gamma, Mu and Lambda, and at least 83 other lineages have predominated locally with a country-specific enrichments. This work has contributed to the understanding of the dynamics of the pandemic in Latin America as part of the local and international efforts to achieve timely genomic surveillance of SARS-CoV-2. Frontiers Media S.A. 2023-03-02 /pmc/articles/PMC10018007/ /pubmed/36935725 http://dx.doi.org/10.3389/fpubh.2023.1095202 Text en Copyright © 2023 Molina-Mora, Reales-González, Camacho, Duarte-Martínez, Tsukayama, Soto-Garita, Brenes, Cordero-Laurent, Ribeiro dos Santos, Guedes Salgado, Santos Silva, Santana de Souza, Nunes, Negri, Vidal, Oliveira, Oliveira, Muñoz-Medina, Salas-Lais, Mireles-Rivera, Sosa, Turjanski, Monzani, Carobene, Remes Lenicov, Schottlender, Fernández Do Porto, Kreuze, Sacristán, Guevara-Suarez, Cristancho, Campos-Sánchez and Herrera-Estrella. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Public Health Molina-Mora, Jose Arturo Reales-González, Jhonnatan Camacho, Erwin Duarte-Martínez, Francisco Tsukayama, Pablo Soto-Garita, Claudio Brenes, Hebleen Cordero-Laurent, Estela Ribeiro dos Santos, Andrea Guedes Salgado, Cláudio Santos Silva, Caio Santana de Souza, Jorge Nunes, Gisele Negri, Tatianne Vidal, Amanda Oliveira, Renato Oliveira, Guilherme Muñoz-Medina, José Esteban Salas-Lais, Angel Gustavo Mireles-Rivera, Guadalupe Sosa, Ezequiel Turjanski, Adrián Monzani, María Cecilia Carobene, Mauricio G. Remes Lenicov, Federico Schottlender, Gustavo Fernández Do Porto, Darío A. Kreuze, Jan Frederik Sacristán, Luisa Guevara-Suarez, Marcela Cristancho, Marco Campos-Sánchez, Rebeca Herrera-Estrella, Alfredo Overview of the SARS-CoV-2 genotypes circulating in Latin America during 2021 |
title | Overview of the SARS-CoV-2 genotypes circulating in Latin America during 2021 |
title_full | Overview of the SARS-CoV-2 genotypes circulating in Latin America during 2021 |
title_fullStr | Overview of the SARS-CoV-2 genotypes circulating in Latin America during 2021 |
title_full_unstemmed | Overview of the SARS-CoV-2 genotypes circulating in Latin America during 2021 |
title_short | Overview of the SARS-CoV-2 genotypes circulating in Latin America during 2021 |
title_sort | overview of the sars-cov-2 genotypes circulating in latin america during 2021 |
topic | Public Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018007/ https://www.ncbi.nlm.nih.gov/pubmed/36935725 http://dx.doi.org/10.3389/fpubh.2023.1095202 |
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