Cargando…
Development of myocarditis and pericarditis after COVID‐19 vaccination in children and adolescents: A systematic review
Myocarditis and pericarditis have been reported after COVID‐19 vaccine administration in children and adolescents, raising the concern about their possible association with these vaccines. The objective was to explore the incidence, clinical presentation, and association of myocarditis and pericardi...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018089/ https://www.ncbi.nlm.nih.gov/pubmed/36594165 http://dx.doi.org/10.1002/clc.23965 |
_version_ | 1784907736295669760 |
---|---|
author | Fatima, Maurish Khan, Muhammad H. A. Ali, Muhammad S. Osama, Muhammad Cheema, Huzaifa A. Ahmed, Aleena Nisar, Amna Murad, Muhammad W. Farooq, Hareem Rehman, Muhammad A. U. Swed, Sarya Akbar, Usman A. |
author_facet | Fatima, Maurish Khan, Muhammad H. A. Ali, Muhammad S. Osama, Muhammad Cheema, Huzaifa A. Ahmed, Aleena Nisar, Amna Murad, Muhammad W. Farooq, Hareem Rehman, Muhammad A. U. Swed, Sarya Akbar, Usman A. |
author_sort | Fatima, Maurish |
collection | PubMed |
description | Myocarditis and pericarditis have been reported after COVID‐19 vaccine administration in children and adolescents, raising the concern about their possible association with these vaccines. The objective was to explore the incidence, clinical presentation, and association of myocarditis and pericarditis with COVID‐19 vaccines in children and adolescents. We conducted a systematic literature search on three databases, that is, Cochrane, MEDLINE/PubMed, and EMBASE from inception till March 2022. A total of three case reports, four case series, and six observational studies were included in the review. For case reports and case series, the mean age of the patients was 17.4 years, with 96.9% being male. Chest pain (n = 31, 93.9%), fever (n = 18, 54.5%), myalgias (n = 15, 45.4%) and headache (n = 9, 27.2%) were the most common presentations. Out of 33 patients, 32 (96.9%) of patients received Pfizer‐BioNTech whereas only one (3.03%) received Moderna (mRNA 1273). Clinical investigations revealed ST elevation (n = 32, 97%), and elevated CRP (n = 9, 27.2%) and cardiac troponin (n = 29, 87.8%). The pooled incidence of myocarditis and pericarditis from observational studies was (0.00063%) and (0.000074%) %, respectively. Myocarditis and pericarditis in children and adolescents after the COVID‐19 vaccines were more prevalent among males and more commonly observed after the second dose of Pfizer. Though the overall incidence was low, however, the clinicians should consider myocarditis and pericarditis as probable diagnosis when encountering young patients, with a history of vaccine administration, presenting with suggestive findings. |
format | Online Article Text |
id | pubmed-10018089 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100180892023-03-17 Development of myocarditis and pericarditis after COVID‐19 vaccination in children and adolescents: A systematic review Fatima, Maurish Khan, Muhammad H. A. Ali, Muhammad S. Osama, Muhammad Cheema, Huzaifa A. Ahmed, Aleena Nisar, Amna Murad, Muhammad W. Farooq, Hareem Rehman, Muhammad A. U. Swed, Sarya Akbar, Usman A. Clin Cardiol Reviews Myocarditis and pericarditis have been reported after COVID‐19 vaccine administration in children and adolescents, raising the concern about their possible association with these vaccines. The objective was to explore the incidence, clinical presentation, and association of myocarditis and pericarditis with COVID‐19 vaccines in children and adolescents. We conducted a systematic literature search on three databases, that is, Cochrane, MEDLINE/PubMed, and EMBASE from inception till March 2022. A total of three case reports, four case series, and six observational studies were included in the review. For case reports and case series, the mean age of the patients was 17.4 years, with 96.9% being male. Chest pain (n = 31, 93.9%), fever (n = 18, 54.5%), myalgias (n = 15, 45.4%) and headache (n = 9, 27.2%) were the most common presentations. Out of 33 patients, 32 (96.9%) of patients received Pfizer‐BioNTech whereas only one (3.03%) received Moderna (mRNA 1273). Clinical investigations revealed ST elevation (n = 32, 97%), and elevated CRP (n = 9, 27.2%) and cardiac troponin (n = 29, 87.8%). The pooled incidence of myocarditis and pericarditis from observational studies was (0.00063%) and (0.000074%) %, respectively. Myocarditis and pericarditis in children and adolescents after the COVID‐19 vaccines were more prevalent among males and more commonly observed after the second dose of Pfizer. Though the overall incidence was low, however, the clinicians should consider myocarditis and pericarditis as probable diagnosis when encountering young patients, with a history of vaccine administration, presenting with suggestive findings. John Wiley and Sons Inc. 2023-01-02 /pmc/articles/PMC10018089/ /pubmed/36594165 http://dx.doi.org/10.1002/clc.23965 Text en © 2023 The Authors. Clinical Cardiology published by Wiley Periodicals, LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Fatima, Maurish Khan, Muhammad H. A. Ali, Muhammad S. Osama, Muhammad Cheema, Huzaifa A. Ahmed, Aleena Nisar, Amna Murad, Muhammad W. Farooq, Hareem Rehman, Muhammad A. U. Swed, Sarya Akbar, Usman A. Development of myocarditis and pericarditis after COVID‐19 vaccination in children and adolescents: A systematic review |
title | Development of myocarditis and pericarditis after COVID‐19 vaccination in children and adolescents: A systematic review |
title_full | Development of myocarditis and pericarditis after COVID‐19 vaccination in children and adolescents: A systematic review |
title_fullStr | Development of myocarditis and pericarditis after COVID‐19 vaccination in children and adolescents: A systematic review |
title_full_unstemmed | Development of myocarditis and pericarditis after COVID‐19 vaccination in children and adolescents: A systematic review |
title_short | Development of myocarditis and pericarditis after COVID‐19 vaccination in children and adolescents: A systematic review |
title_sort | development of myocarditis and pericarditis after covid‐19 vaccination in children and adolescents: a systematic review |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018089/ https://www.ncbi.nlm.nih.gov/pubmed/36594165 http://dx.doi.org/10.1002/clc.23965 |
work_keys_str_mv | AT fatimamaurish developmentofmyocarditisandpericarditisaftercovid19vaccinationinchildrenandadolescentsasystematicreview AT khanmuhammadha developmentofmyocarditisandpericarditisaftercovid19vaccinationinchildrenandadolescentsasystematicreview AT alimuhammads developmentofmyocarditisandpericarditisaftercovid19vaccinationinchildrenandadolescentsasystematicreview AT osamamuhammad developmentofmyocarditisandpericarditisaftercovid19vaccinationinchildrenandadolescentsasystematicreview AT cheemahuzaifaa developmentofmyocarditisandpericarditisaftercovid19vaccinationinchildrenandadolescentsasystematicreview AT ahmedaleena developmentofmyocarditisandpericarditisaftercovid19vaccinationinchildrenandadolescentsasystematicreview AT nisaramna developmentofmyocarditisandpericarditisaftercovid19vaccinationinchildrenandadolescentsasystematicreview AT muradmuhammadw developmentofmyocarditisandpericarditisaftercovid19vaccinationinchildrenandadolescentsasystematicreview AT farooqhareem developmentofmyocarditisandpericarditisaftercovid19vaccinationinchildrenandadolescentsasystematicreview AT rehmanmuhammadau developmentofmyocarditisandpericarditisaftercovid19vaccinationinchildrenandadolescentsasystematicreview AT swedsarya developmentofmyocarditisandpericarditisaftercovid19vaccinationinchildrenandadolescentsasystematicreview AT akbarusmana developmentofmyocarditisandpericarditisaftercovid19vaccinationinchildrenandadolescentsasystematicreview |