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Transarterial arterial sclerosing embolization for the treatment of propranolol-resistant subglottic hemangioma: Feasibility and effificacy

PURPOSE: To assess the effectiveness and safety of transcatheter arterial sclerosing embolization (TASE) for the treatment of subglottic hemangiomas that did not respond appreciably to propranolol. MATERIALS AND METHODS: This study was a retrospective analysis. Of the 101 patients with subglottic he...

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Autores principales: Liu, Zhuang, Song, Dan, Wang, Liang, Zhou, Jie, Wang, Changfeng, Li, Jing, Sun, Jiali, Zhang, Xian, Guo, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018163/
https://www.ncbi.nlm.nih.gov/pubmed/36937450
http://dx.doi.org/10.3389/fonc.2023.1062510
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author Liu, Zhuang
Song, Dan
Wang, Liang
Zhou, Jie
Wang, Changfeng
Li, Jing
Sun, Jiali
Zhang, Xian
Guo, Lei
author_facet Liu, Zhuang
Song, Dan
Wang, Liang
Zhou, Jie
Wang, Changfeng
Li, Jing
Sun, Jiali
Zhang, Xian
Guo, Lei
author_sort Liu, Zhuang
collection PubMed
description PURPOSE: To assess the effectiveness and safety of transcatheter arterial sclerosing embolization (TASE) for the treatment of subglottic hemangiomas that did not respond appreciably to propranolol. MATERIALS AND METHODS: This study was a retrospective analysis. Of the 101 patients with subglottic hemangiomas admitted to our center, 10 (4 male and 6 female) patients were included in this study. All these patients underwent arterial embolization using Pingyangmycin and polyvinyl alcohol particles (300–500 μm). All patients were examined 1 month after the last treatment and monthly thereafter. RESULTS: TASE treatment was technically successful in all patients. Ten lesions were located in the subglottic region. The blood supply included the superior thyroid artery, brachiocephalic trunk, facial artery, and ascending pharyngeal arteries. The median maximal diameter of the hemangiomas significantly decreased from 8.5 mm before treatment to 2 mm after TASE (P <.05). The degree of laryngeal obstruction improved in all patients. No serious complications were noted. One patient developed fever postoperatively, and three patients had a mild cough. CONCLUSIONS: For even subglottic hemangiomas with suboptimal efficacy of propranolol, TASE significantly reduced the size of hemangiomas with minimal adverse effects. It had a positive effect on the improvement of airway stenosis caused by subglottic hemangioma with poor effect of oral propranolol.
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spelling pubmed-100181632023-03-17 Transarterial arterial sclerosing embolization for the treatment of propranolol-resistant subglottic hemangioma: Feasibility and effificacy Liu, Zhuang Song, Dan Wang, Liang Zhou, Jie Wang, Changfeng Li, Jing Sun, Jiali Zhang, Xian Guo, Lei Front Oncol Oncology PURPOSE: To assess the effectiveness and safety of transcatheter arterial sclerosing embolization (TASE) for the treatment of subglottic hemangiomas that did not respond appreciably to propranolol. MATERIALS AND METHODS: This study was a retrospective analysis. Of the 101 patients with subglottic hemangiomas admitted to our center, 10 (4 male and 6 female) patients were included in this study. All these patients underwent arterial embolization using Pingyangmycin and polyvinyl alcohol particles (300–500 μm). All patients were examined 1 month after the last treatment and monthly thereafter. RESULTS: TASE treatment was technically successful in all patients. Ten lesions were located in the subglottic region. The blood supply included the superior thyroid artery, brachiocephalic trunk, facial artery, and ascending pharyngeal arteries. The median maximal diameter of the hemangiomas significantly decreased from 8.5 mm before treatment to 2 mm after TASE (P <.05). The degree of laryngeal obstruction improved in all patients. No serious complications were noted. One patient developed fever postoperatively, and three patients had a mild cough. CONCLUSIONS: For even subglottic hemangiomas with suboptimal efficacy of propranolol, TASE significantly reduced the size of hemangiomas with minimal adverse effects. It had a positive effect on the improvement of airway stenosis caused by subglottic hemangioma with poor effect of oral propranolol. Frontiers Media S.A. 2023-03-02 /pmc/articles/PMC10018163/ /pubmed/36937450 http://dx.doi.org/10.3389/fonc.2023.1062510 Text en Copyright © 2023 Liu, Song, Wang, Zhou, Wang, Li, Sun, Zhang and Guo https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Liu, Zhuang
Song, Dan
Wang, Liang
Zhou, Jie
Wang, Changfeng
Li, Jing
Sun, Jiali
Zhang, Xian
Guo, Lei
Transarterial arterial sclerosing embolization for the treatment of propranolol-resistant subglottic hemangioma: Feasibility and effificacy
title Transarterial arterial sclerosing embolization for the treatment of propranolol-resistant subglottic hemangioma: Feasibility and effificacy
title_full Transarterial arterial sclerosing embolization for the treatment of propranolol-resistant subglottic hemangioma: Feasibility and effificacy
title_fullStr Transarterial arterial sclerosing embolization for the treatment of propranolol-resistant subglottic hemangioma: Feasibility and effificacy
title_full_unstemmed Transarterial arterial sclerosing embolization for the treatment of propranolol-resistant subglottic hemangioma: Feasibility and effificacy
title_short Transarterial arterial sclerosing embolization for the treatment of propranolol-resistant subglottic hemangioma: Feasibility and effificacy
title_sort transarterial arterial sclerosing embolization for the treatment of propranolol-resistant subglottic hemangioma: feasibility and effificacy
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018163/
https://www.ncbi.nlm.nih.gov/pubmed/36937450
http://dx.doi.org/10.3389/fonc.2023.1062510
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