An intellectual disability-related MED23 mutation dysregulates gene expression by altering chromatin conformation and enhancer activities

Transcriptional Mediator controls diverse gene programs for various developmental and pathological processes. The human Mediator MED23/R617Q mutation was reported in a familial intellectual disability (ID) disorder, although the underlying mechanisms remain poorly understood. Constructed by gene edi...

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Detalles Bibliográficos
Autores principales: Yang, Yenan, Li, Chonghui, Chen, Ziyin, Zhang, Yiyang, Tian, Qing, Sun, Meiling, Zhang, Shuai, Yu, Miao, Wang, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018335/
https://www.ncbi.nlm.nih.gov/pubmed/36718943
http://dx.doi.org/10.1093/nar/gkad025

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