DNA polymerase θ-mediated repair of high LET radiation-induced complex DNA double-strand breaks

DNA polymerase θ (POLQ) is a unique DNA polymerase that is able to perform microhomology-mediated end-joining as well as translesion synthesis (TLS) across an abasic (AP) site and thymine glycol (Tg). However, the biological significance of the TLS activity is currently unknown. Herein we provide ev...

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Detalles Bibliográficos
Autores principales: Yi, Geunil, Sung, Yubin, Kim, Chanwoo, Ra, Jae Sun, Hirakawa, Hirokazu, Kato, Takamitsu A, Fujimori, Akira, Kim, Hajin, Takata, Kei-ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018357/
https://www.ncbi.nlm.nih.gov/pubmed/36805268
http://dx.doi.org/10.1093/nar/gkad076

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018357/
https://www.ncbi.nlm.nih.gov/pubmed/36805268
http://dx.doi.org/10.1093/nar/gkad076

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