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Revealing determinants of translation efficiency via whole-gene codon randomization and machine learning

It has been known for decades that codon usage contributes to translation efficiency and hence to protein production levels. However, its role in protein synthesis is still only partly understood. This lack of understanding hampers the design of synthetic genes for efficient protein production. In t...

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Detalles Bibliográficos
Autores principales:	Nieuwkoop, Thijs, Terlouw, Barbara R, Stevens, Katherine G, Scheltema, Richard A, de Ridder, Dick, van der Oost, John, Claassens, Nico J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018363/ https://www.ncbi.nlm.nih.gov/pubmed/36718935 http://dx.doi.org/10.1093/nar/gkad035

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