Cargando…

Cryo-EM structure of the fully assembled Elongator complex

Transfer RNA (tRNA) molecules are essential to decode messenger RNA codons during protein synthesis. All known tRNAs are heavily modified at multiple positions through post-transcriptional addition of chemical groups. Modifications in the tRNA anticodons are directly influencing ribosome decoding an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jaciuk, Marcin, Scherf, David, Kaszuba, Karol, Gaik, Monika, Rau, Alexander, Kościelniak, Anna, Krutyhołowa, Rościsław, Rawski, Michał, Indyka, Paulina, Graziadei, Andrea, Chramiec-Głąbik, Andrzej, Biela, Anna, Dobosz, Dominika, Lin, Ting-Yu, Abbassi, Nour-el-Hana, Hammermeister, Alexander, Rappsilber, Juri, Kosinski, Jan, Schaffrath, Raffael, Glatt, Sebastian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	NAR Breakthrough Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018365/ https://www.ncbi.nlm.nih.gov/pubmed/36617428 http://dx.doi.org/10.1093/nar/gkac1232

Ejemplares similares

Fungal Kti12 proteins display unusual linker regions and unique ATPase p-loops
por: Krutyhołowa, Rościsław, et al.
Publicado: (2020)

Secondary structure determination of conserved SARS-CoV-2 RNA elements by NMR spectroscopy
por: Wacker, Anna, et al.
Publicado: (2020)

Adenovirus prevents dsRNA formation by promoting efficient splicing of viral RNA
por: Price, Alexander M, et al.
Publicado: (2021)

Induction of the alternative lengthening of telomeres pathway by trapping of proteins on DNA
por: Rose, Anna M, et al.
Publicado: (2023)

PARP1 catalytic variants reveal branching and chain length-specific functions of poly(ADP-ribose) in cellular physiology and stress response
por: Aberle, Lisa, et al.
Publicado: (2020)

The Virtual Metabolic Human database: integrating human and gut microbiome metabolism with nutrition and disease
por: Noronha, Alberto, et al.
Publicado: (2019)

Kti12, a PSTK-like tRNA dependent ATPase essential for tRNA modification by Elongator
por: Krutyhołowa, Rościsław, et al.
Publicado: (2019)

Biogenesis and growth phase-dependent alteration of 5-methoxycarbonylmethoxyuridine in tRNA anticodons
por: Sakai, Yusuke, et al.
Publicado: (2016)

Automated physics-based design of synthetic riboswitches from diverse RNA aptamers
por: Espah Borujeni, Amin, et al.
Publicado: (2016)

The STAR protein QKI-7 recruits PAPD4 to regulate post-transcriptional polyadenylation of target mRNAs
por: Yamagishi, Ryota, et al.
Publicado: (2016)

Identification of a mismatch-specific endonuclease in hyperthermophilic Archaea
por: Ishino, Sonoko, et al.
Publicado: (2016)

Reversible acetylation on Lys501 regulates the activity of RNase II
por: Song, Limin, et al.
Publicado: (2016)

Methylation of histone H3 lysine 9 occurs during translation
por: Rivera, Carlos, et al.
Publicado: (2015)

Structure of a human translation termination complex
por: Matheisl, Sarah, et al.
Publicado: (2015)

Antisense oligonucleotides delivered to the amniotic cavity in utero modulate gene expression in the postnatal mouse
por: Depreux, Frederic F., et al.
Publicado: (2016)

A novel role for poly(C) binding proteins in programmed ribosomal frameshifting
por: Napthine, Sawsan, et al.
Publicado: (2016)

High-resolution structure of the presynaptic RAD51 filament on single-stranded DNA by electron cryo-microscopy
por: Short, Judith M., et al.
Publicado: (2016)

Mitochondrial DNA exhibits resistance to induced point and deletion mutations
por: Valente, William J., et al.
Publicado: (2016)

3.9 Å structure of the nucleosome core particle determined by phase-plate cryo-EM
por: Chua, Eugene Y.D., et al.
Publicado: (2016)

Division of labor among Mycobacterium smegmatis RNase H enzymes: RNase H1 activity of RnhA or RnhC is essential for growth whereas RnhB and RnhA guard against killing by hydrogen peroxide in stationary phase
por: Gupta, Richa, et al.
Publicado: (2017)

DNA-assisted oligomerization of pore-forming toxin monomers into precisely-controlled protein channels
por: Henning-Knechtel, Anja, et al.
Publicado: (2017)

A single active site in the mariner transposase cleaves DNA strands of opposite polarity
por: Claeys Bouuaert, Corentin, et al.
Publicado: (2017)

The mechanisms of a mammalian splicing enhancer
por: Jobbins, Andrew M, et al.
Publicado: (2018)

Logical engineering of D-arm and T-stem of tRNA that enhances d-amino acid incorporation
por: Katoh, Takayuki, et al.
Publicado: (2017)

Analysis of in vitro evolution reveals the underlying distribution of catalytic activity among random sequences
por: Pressman, Abe, et al.
Publicado: (2017)

Subtelomeres constitute a safeguard for gene expression and chromosome homeostasis
por: Tashiro, Sanki, et al.
Publicado: (2017)

Proteomic identification of histone post-translational modifications and proteins enriched at a DNA double-strand break
por: Wang, Pingping, et al.
Publicado: (2017)

Prespacer processing and specific integration in a Type I-A CRISPR system
por: Rollie, Clare, et al.
Publicado: (2018)

Metabolic and chemical regulation of tRNA modification associated with taurine deficiency and human disease
por: Asano, Kana, et al.
Publicado: (2018)

An interplay of miRNA abundance and target site architecture determines miRNA activity and specificity
por: Brancati, Giovanna, et al.
Publicado: (2018)

Structure of HIV TAR in complex with a Lab-Evolved RRM provides insight into duplex RNA recognition and synthesis of a constrained peptide that impairs transcription
por: Belashov, Ivan A, et al.
Publicado: (2018)

Generating genomic platforms to study Candida albicans pathogenesis
por: Legrand, Mélanie, et al.
Publicado: (2018)

Extensive and systematic rewiring of histone post-translational modifications in cancer model systems
por: Noberini, Roberta, et al.
Publicado: (2018)

The arginine methyltransferase CARM1 represses p300•ACT•CREMτ activity and is required for spermiogenesis
por: Bao, Jianqiang, et al.
Publicado: (2018)

Antisense oligonucleotides correct the familial dysautonomia splicing defect in IKBKAP transgenic mice
por: Sinha, Rahul, et al.
Publicado: (2018)

Designer tRNAs for efficient incorporation of non-canonical amino acids by the pyrrolysine system in mammalian cells
por: Serfling, Robert, et al.
Publicado: (2018)

Reconstitution of the CstF complex unveils a regulatory role for CstF-50 in recognition of 3′-end processing signals
por: Yang, Wen, et al.
Publicado: (2018)

3′ end additions by T7 RNA polymerase are RNA self-templated, distributive and diverse in character—RNA-Seq analyses
por: Gholamalipour, Yasaman, et al.
Publicado: (2018)

Recombination is required for efficient HIV-1 replication and the maintenance of viral genome integrity
por: Rawson, Jonathan M O, et al.
Publicado: (2018)

Single-nucleotide-resolution sequencing of human N(6)-methyldeoxyadenosine reveals strand-asymmetric clusters associated with SSBP1 on the mitochondrial genome
por: Koh, Casslynn W Q, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_lvs5i0693eqaojpltkn3the90u