PARP1 associates with R-loops to promote their resolution and genome stability

PARP1 is a DNA-dependent ADP-Ribose transferase with ADP-ribosylation activity that is triggered by DNA breaks and non-B DNA structures to mediate their resolution. PARP1 was also recently identified as a component of the R-loop-associated protein-protein interaction network, suggesting a potential...

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Detalles Bibliográficos
Autores principales: Laspata, Natalie, Kaur, Parminder, Mersaoui, Sofiane Yacine, Muoio, Daniela, Liu, Zhiyan Silvia, Bannister, Maxwell Henry, Nguyen, Hai Dang, Curry, Caroline, Pascal, John M, Poirier, Guy G, Wang, Hong, Masson, Jean-Yves, Fouquerel, Elise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018367/
https://www.ncbi.nlm.nih.gov/pubmed/36794853
http://dx.doi.org/10.1093/nar/gkad066

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