Targeting carcinoembryonic antigen-expressing tumors using a novel transcriptional and translational dual-regulated oncolytic herpes simplex virus type 1

VG2025 is a recombinant oncolytic herpes simplex virus type 1 (HSV-1) that uses transcriptional and translational dual regulation (TTDR) of critical viral genes to enhance virus safety and promote tumor-specific virus replication without reducing virulence. The TTDR platform is based on transcriptio...

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Detalles Bibliográficos
Autores principales: Chouljenko, Dmitry V., Murad, Yanal M., Lee, I-Fang, Delwar, Zahid, Ding, Jun, Liu, Guoyu, Liu, Xiaohu, Bu, Xuexian, Sun, Yi, Samudio, Ismael, Jia, William Wei-Guo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018392/
https://www.ncbi.nlm.nih.gov/pubmed/36938544
http://dx.doi.org/10.1016/j.omto.2023.02.003

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