Cargando…
Idiopathic Acroosteolysis: A Novel Cutaneous Sign Can Help Identify the Condition Early
Acroosteolysis (AO) is a rare condition characterized by resorption of the distal phalanges of the fingers and/or toes. It can be familial, idiopathic (IAO), occupational, or secondary. Other authors suggest a classification into primary (genetic disorders, lysosomal storage disorders) or secondary...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018418/ https://www.ncbi.nlm.nih.gov/pubmed/36936732 http://dx.doi.org/10.1159/000529727 |
_version_ | 1784907804443672576 |
---|---|
author | Shrestha, Samir Regmi, Bashant Pathak, Raksha Kroumpouzos, George |
author_facet | Shrestha, Samir Regmi, Bashant Pathak, Raksha Kroumpouzos, George |
author_sort | Shrestha, Samir |
collection | PubMed |
description | Acroosteolysis (AO) is a rare condition characterized by resorption of the distal phalanges of the fingers and/or toes. It can be familial, idiopathic (IAO), occupational, or secondary. Other authors suggest a classification into primary (genetic disorders, lysosomal storage disorders) or secondary AO. Various skin and nail changes have been reported in this condition. However, the cutaneous change on the affected digit(s)/toe(s) during the natural course of AO has been poorly documented. A 5-year-old girl presented with a 3-month history of a distinct transverse boundary between normal skin proximally and affected crusted skin overlying osteolysis distally (“split” sign) on the plantar surface of the third toe. This boundary gradually elongated circumferentially to involve the dorsal surface. The mother gave a similar history of a delimitation line on the 2nd, 4th, and 5th toes of the right foot with durations of 3 months, 1 year, and 2 years, respectively, that disappeared before she noticed a shortening of those toes. X-rays revealed partial resorption of the terminal phalanx of the third toe and several lytic changes in the middle and terminal phalanx of the second, fourth, and fifth toes. The clinical features, radiology findings, and a workup that helped rule out conditions associated with AO (secondary AO) helped establish the diagnosis of IAO in our patient. This case study highlights that the natural course of IAO includes distinct skin findings, such as the “split” sign that we describe. This sign can help identify the condition early. |
format | Online Article Text |
id | pubmed-10018418 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-100184182023-03-17 Idiopathic Acroosteolysis: A Novel Cutaneous Sign Can Help Identify the Condition Early Shrestha, Samir Regmi, Bashant Pathak, Raksha Kroumpouzos, George Case Rep Dermatol Single Case Acroosteolysis (AO) is a rare condition characterized by resorption of the distal phalanges of the fingers and/or toes. It can be familial, idiopathic (IAO), occupational, or secondary. Other authors suggest a classification into primary (genetic disorders, lysosomal storage disorders) or secondary AO. Various skin and nail changes have been reported in this condition. However, the cutaneous change on the affected digit(s)/toe(s) during the natural course of AO has been poorly documented. A 5-year-old girl presented with a 3-month history of a distinct transverse boundary between normal skin proximally and affected crusted skin overlying osteolysis distally (“split” sign) on the plantar surface of the third toe. This boundary gradually elongated circumferentially to involve the dorsal surface. The mother gave a similar history of a delimitation line on the 2nd, 4th, and 5th toes of the right foot with durations of 3 months, 1 year, and 2 years, respectively, that disappeared before she noticed a shortening of those toes. X-rays revealed partial resorption of the terminal phalanx of the third toe and several lytic changes in the middle and terminal phalanx of the second, fourth, and fifth toes. The clinical features, radiology findings, and a workup that helped rule out conditions associated with AO (secondary AO) helped establish the diagnosis of IAO in our patient. This case study highlights that the natural course of IAO includes distinct skin findings, such as the “split” sign that we describe. This sign can help identify the condition early. S. Karger AG 2023-03-15 /pmc/articles/PMC10018418/ /pubmed/36936732 http://dx.doi.org/10.1159/000529727 Text en © 2023 The Author(s). Published by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission. |
spellingShingle | Single Case Shrestha, Samir Regmi, Bashant Pathak, Raksha Kroumpouzos, George Idiopathic Acroosteolysis: A Novel Cutaneous Sign Can Help Identify the Condition Early |
title | Idiopathic Acroosteolysis: A Novel Cutaneous Sign Can Help Identify the Condition Early |
title_full | Idiopathic Acroosteolysis: A Novel Cutaneous Sign Can Help Identify the Condition Early |
title_fullStr | Idiopathic Acroosteolysis: A Novel Cutaneous Sign Can Help Identify the Condition Early |
title_full_unstemmed | Idiopathic Acroosteolysis: A Novel Cutaneous Sign Can Help Identify the Condition Early |
title_short | Idiopathic Acroosteolysis: A Novel Cutaneous Sign Can Help Identify the Condition Early |
title_sort | idiopathic acroosteolysis: a novel cutaneous sign can help identify the condition early |
topic | Single Case |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018418/ https://www.ncbi.nlm.nih.gov/pubmed/36936732 http://dx.doi.org/10.1159/000529727 |
work_keys_str_mv | AT shresthasamir idiopathicacroosteolysisanovelcutaneoussigncanhelpidentifytheconditionearly AT regmibashant idiopathicacroosteolysisanovelcutaneoussigncanhelpidentifytheconditionearly AT pathakraksha idiopathicacroosteolysisanovelcutaneoussigncanhelpidentifytheconditionearly AT kroumpouzosgeorge idiopathicacroosteolysisanovelcutaneoussigncanhelpidentifytheconditionearly |