Recent findings on miR‑370 expression, regulation and functions in cancer (Review)

MicroRNAs (miRNAs/miRs) are a group of small non-coding RNAs that serve as post-transcriptional gene modulators. miRNAs have been demonstrated to serve a pivotal role in carcinogenesis and the dysregulated expression of miRNAs is a well-understood characteristic of cancer. In recent years, miR-370 has been established as a key miRNA in various cancers. The expression of miR-370 is dysregulated in various types of cancer and varies markedly across different tumor types. miR-370 can regulate multiple biological processes, including cell proliferation, apoptosis, migration, invasion, as well as cell cycle progression and cell stemness. Moreover, it has been reported that miR-370 affects the response of tumor cells to anticancer treatments. Additionally, the expression of miR-370 is modulated by multiple factors. The present review summarizes the role and mechanism of miR-370 in tumors, and demonstrates its potential as a molecular marker for cancer diagnosis and prognosis.