National Cancer Institute (NCI) Program for Natural Product Discovery: Exploring NCI-60 Screening Data of Natural Product Samples with Artificial Neural Networks

[Image: see text] National Cancer Institute (NCI) Program for Natural Product Discovery is a new initiative aimed at creating new technologies for natural product-based drug discovery. Here, we present the development of a neural network-based bioinformatics platform for visualization and analysis o...

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Detalles Bibliográficos
Autores principales: Evans, Jason R., Akee, Rhone K., Chanana, Shaurya, McConachie, Grant D., Thornburg, Christopher C., Grkovic, Tanja, O’Keefe, Barry R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018511/
https://www.ncbi.nlm.nih.gov/pubmed/36936303
http://dx.doi.org/10.1021/acsomega.2c07416
Descripción
Sumario:[Image: see text] National Cancer Institute (NCI) Program for Natural Product Discovery is a new initiative aimed at creating new technologies for natural product-based drug discovery. Here, we present the development of a neural network-based bioinformatics platform for visualization and analysis of natural product high-throughput screening data using the NCI’s 60 human tumor cell anticancer drug screen. We demonstrate how the tool enables visualization of similar patterns of response that can be parsed both chemically and taxonomically, grouping NCI-60 biological profiles in one easy-to-use bioinformatics interface.

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