National Cancer Institute (NCI) Program for Natural Product Discovery: Exploring NCI-60 Screening Data of Natural Product Samples with Artificial Neural Networks

[Image: see text] National Cancer Institute (NCI) Program for Natural Product Discovery is a new initiative aimed at creating new technologies for natural product-based drug discovery. Here, we present the development of a neural network-based bioinformatics platform for visualization and analysis o...

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Autores principales: Evans, Jason R., Akee, Rhone K., Chanana, Shaurya, McConachie, Grant D., Thornburg, Christopher C., Grkovic, Tanja, O’Keefe, Barry R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018511/
https://www.ncbi.nlm.nih.gov/pubmed/36936303
http://dx.doi.org/10.1021/acsomega.2c07416
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author Evans, Jason R.
Akee, Rhone K.
Chanana, Shaurya
McConachie, Grant D.
Thornburg, Christopher C.
Grkovic, Tanja
O’Keefe, Barry R.
author_facet Evans, Jason R.
Akee, Rhone K.
Chanana, Shaurya
McConachie, Grant D.
Thornburg, Christopher C.
Grkovic, Tanja
O’Keefe, Barry R.
author_sort Evans, Jason R.
collection PubMed
description [Image: see text] National Cancer Institute (NCI) Program for Natural Product Discovery is a new initiative aimed at creating new technologies for natural product-based drug discovery. Here, we present the development of a neural network-based bioinformatics platform for visualization and analysis of natural product high-throughput screening data using the NCI’s 60 human tumor cell anticancer drug screen. We demonstrate how the tool enables visualization of similar patterns of response that can be parsed both chemically and taxonomically, grouping NCI-60 biological profiles in one easy-to-use bioinformatics interface.
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spelling pubmed-100185112023-03-17 National Cancer Institute (NCI) Program for Natural Product Discovery: Exploring NCI-60 Screening Data of Natural Product Samples with Artificial Neural Networks Evans, Jason R. Akee, Rhone K. Chanana, Shaurya McConachie, Grant D. Thornburg, Christopher C. Grkovic, Tanja O’Keefe, Barry R. ACS Omega [Image: see text] National Cancer Institute (NCI) Program for Natural Product Discovery is a new initiative aimed at creating new technologies for natural product-based drug discovery. Here, we present the development of a neural network-based bioinformatics platform for visualization and analysis of natural product high-throughput screening data using the NCI’s 60 human tumor cell anticancer drug screen. We demonstrate how the tool enables visualization of similar patterns of response that can be parsed both chemically and taxonomically, grouping NCI-60 biological profiles in one easy-to-use bioinformatics interface. American Chemical Society 2023-03-01 /pmc/articles/PMC10018511/ /pubmed/36936303 http://dx.doi.org/10.1021/acsomega.2c07416 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Evans, Jason R.
Akee, Rhone K.
Chanana, Shaurya
McConachie, Grant D.
Thornburg, Christopher C.
Grkovic, Tanja
O’Keefe, Barry R.
National Cancer Institute (NCI) Program for Natural Product Discovery: Exploring NCI-60 Screening Data of Natural Product Samples with Artificial Neural Networks
title National Cancer Institute (NCI) Program for Natural Product Discovery: Exploring NCI-60 Screening Data of Natural Product Samples with Artificial Neural Networks
title_full National Cancer Institute (NCI) Program for Natural Product Discovery: Exploring NCI-60 Screening Data of Natural Product Samples with Artificial Neural Networks
title_fullStr National Cancer Institute (NCI) Program for Natural Product Discovery: Exploring NCI-60 Screening Data of Natural Product Samples with Artificial Neural Networks
title_full_unstemmed National Cancer Institute (NCI) Program for Natural Product Discovery: Exploring NCI-60 Screening Data of Natural Product Samples with Artificial Neural Networks
title_short National Cancer Institute (NCI) Program for Natural Product Discovery: Exploring NCI-60 Screening Data of Natural Product Samples with Artificial Neural Networks
title_sort national cancer institute (nci) program for natural product discovery: exploring nci-60 screening data of natural product samples with artificial neural networks
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018511/
https://www.ncbi.nlm.nih.gov/pubmed/36936303
http://dx.doi.org/10.1021/acsomega.2c07416
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