Synthetic multiantigen MVA vaccine COH04S1 and variant-specific derivatives protect Syrian hamsters from SARS-CoV-2 Omicron subvariants

Emerging SARS-CoV-2 Omicron subvariants continue to disrupt COVID-19 vaccine efficacy through multiple immune mechanisms including neutralizing antibody evasion. We developed COH04S1, a synthetic modified vaccinia Ankara vector that co-expresses Wuhan-Hu-1-based spike and nucleocapsid antigens. COH0...

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Detalles Bibliográficos
Autores principales: Wussow, Felix, Kha, Mindy, Kim, Taehyun, Ly, Minh, Yll-Pico, Marcal, Kar, Swagata, Lewis, Mark G., Chiuppesi, Flavia, Diamond, Don J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018591/
https://www.ncbi.nlm.nih.gov/pubmed/36928589
http://dx.doi.org/10.1038/s41541-023-00640-y

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