Cargando…

The D-amino acid oxidase inhibitor luvadaxistat improves mismatch negativity in patients with schizophrenia in a randomized trial

Several attempts have been made to enhance N-methyl-D-aspartate (NMDA) receptor function in schizophrenia, but they have yielded mixed results. Luvadaxistat, a D-amino acid oxidase (DAAO) inhibitor that increases the glutamate co-agonist D-serine levels, is being developed for the treatment of cogni...

Descripción completa

Detalles Bibliográficos
Autores principales:	O’Donnell, Patricio, Dong, Cheng, Murthy, Venkatesha, Asgharnejad, Mahnaz, Du, Xiaoming, Summerfelt, Ann, Lu, Hong, Xu, Lin, Wendland, Jens R., Dunayevich, Eduardo, Buhl, Derek L., Litman, Robert, Hetrick, William P., Hong, L. Elliot, Rosen, Laura B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018616/ https://www.ncbi.nlm.nih.gov/pubmed/36928351 http://dx.doi.org/10.1038/s41386-023-01560-0

Ejemplares similares

Central nervous system effects of TAK-653, an investigational alpha-amino-3-hydroxy-5-methyl-4-isoxazole receptor (AMPAR) positive allosteric modulator in healthy volunteers
por: Dijkstra, Francis, et al.
Publicado: (2022)

Luvadaxistat: A Novel Potent and Selective d-Amino Acid Oxidase Inhibitor Improves Cognitive and Social Deficits in Rodent Models for Schizophrenia
por: Fradley, Rosa, et al.
Publicado: (2023)

Correction to: Luvadaxistat: A Novel Potent and Selective d-Amino Acid Oxidase Inhibitor Improves Cognitive and Social Deficits in Rodent Models for Schizophrenia
por: Fradley, Rosa, et al.
Publicado: (2023)

Results of a randomized double‐blind study evaluating luvadaxistat in adults with Friedreich ataxia
por: Wang, Hao, et al.
Publicado: (2021)

Transcranial magnetic stimulation as a translational biomarker for AMPA receptor modulation
por: O’Donnell, Patricio, et al.
Publicado: (2021)

Strategies to Address Challenges in Neuroscience Drug Discovery and Development
por: O’Donnell, Patricio, et al.
Publicado: (2019)

Transcriptome-wide association study reveals two genes that influence mismatch negativity
por: Bhat, Anjali, et al.
Publicado: (2021)

Brain Connectivity Signature Extractions from TMS Invoked EEGs
por: Gupta, Deepa, et al.
Publicado: (2023)

Assessment of brain cholesterol metabolism biomarker 24S-hydroxycholesterol in schizophrenia
por: Chiappelli, Joshua, et al.
Publicado: (2020)

Effects of NMDA and GABA-A Receptor Antagonism on Auditory Steady-State Synchronization in Awake Behaving Rats
por: Sullivan, Elyse M., et al.
Publicado: (2015)

Involvement of the β Clamp in Methyl-directed Mismatch Repair in Vitro
por: Pluciennik, Anna, et al.
Publicado: (2009)

Schizophrenia-associated SLC39A8 polymorphism is a loss-of-function allele altering glutamate receptor and innate immune signaling
por: Tseng, Wei Chou, et al.
Publicado: (2021)

Comparing the Incidence of Falls/Fractures in Parkinson’s Disease Patients in the US Population
por: Kalilani, Linda, et al.
Publicado: (2016)

The characteristics and treatment patterns of patients with Parkinson’s disease in the United States and United Kingdom: A retrospective cohort study
por: Kalilani, Linda, et al.
Publicado: (2019)

Hyperactivity and Hypermotivation Associated With Increased Striatal mGluR1 Signaling in a Shank2 Rat Model of Autism
por: Modi, Meera E., et al.
Publicado: (2018)

Postural Control in Bipolar Disorder: Increased Sway Area and Decreased Dynamical Complexity
por: Bolbecker, Amanda R., et al.
Publicado: (2011)

GluN2D-mediated excitatory drive onto medial prefrontal cortical PV+ fast-spiking inhibitory interneurons
por: Garst-Orozco, Jonathan, et al.
Publicado: (2020)

Mapping local and long-distance resting connectivity markers of TMS-related inhibition reduction in schizophrenia
por: Hare, Stephanie M., et al.
Publicado: (2021)

Eyeblink Conditioning in Schizophrenia: A Critical Review
por: Kent, Jerillyn S., et al.
Publicado: (2015)

Rotigotine in Combination with the MAO-B Inhibitor Selegiline in Early Parkinson’s Disease: A Post Hoc Analysis
por: Giladi, Nir, et al.
Publicado: (2016)

Decision Making and Impulsivity in Young Adult Cannabis Users
por: O'Donnell, Brian F., et al.
Publicado: (2021)

Motor Deficits in Schizophrenia Quantified by Nonlinear Analysis of Postural Sway
por: Kent, Jerillyn S., et al.
Publicado: (2012)

Amphetamine Derivatives as Monoamine Oxidase Inhibitors
por: Reyes-Parada, Miguel, et al.
Publicado: (2020)

Randomized controlled study to evaluate the efficacy and safety of soticlestat as adjunctive therapy in adults with complex regional pain syndrome
por: Ratcliffe, Stuart, et al.
Publicado: (2022)

Many Roads to Motor Deficits: Loss of Dopamine Signaling in Direct or Indirect Basal Ganglia Pathway Leads to Akinesia through Distinct Physiological Mechanisms
por: Calhoon, Gwendolyn G., et al.
Publicado: (2010)

α-Arrestins participate in cargo selection for both clathrin-independent and clathrin-mediated endocytosis
por: Prosser, Derek C., et al.
Publicado: (2015)

A Look at the First Quarantined Community in the USA: Response of Religious Communal Organizations and Implications for Public Health During the COVID-19 Pandemic
por: Weinberger-Litman, Sarah L., et al.
Publicado: (2020)

Psychosocial experiences of the internet in a group of adolescents: A qualitative content analysis
por: Mahdizadeh, Mehrsadat, et al.
Publicado: (2017)

Risk factors for impulse control disorders and related behaviors in Parkinson’s disease: secondary analyses of the ICARUS study
por: Barone, Paolo, et al.
Publicado: (2019)

Development and standardization of Mysore Tridosha scale
por: Shilpa, S., et al.
Publicado: (2011)

Understanding personality from Ayurvedic perspective for psychological assessment: A case
por: Shilpa, S, et al.
Publicado: (2011)

Speaker 3: Patricio O’Donnell, USA
por: O’Donnell, Patricio, et al.
Publicado: (2016)

Synchronization dynamics and evidence for a repertoire of network states in resting EEG
por: Betzel, Richard F., et al.
Publicado: (2012)

New Insights into the Nature of Cerebellar-Dependent Eyeblink Conditioning Deficits in Schizophrenia: A Hierarchical Linear Modeling Approach
por: Bolbecker, Amanda R., et al.
Publicado: (2016)

Developing Social Media-Based Suicide Prevention Messages in Partnership With Young People: Exploratory Study
por: Robinson, Jo, et al.
Publicado: (2017)

An Investigation of Neurochemical Changes in Chronic Cannabis Users
por: Newman, Sharlene D., et al.
Publicado: (2019)

Population pharmacokinetics, enzyme occupancy, and 24S‐hydroxycholesterol modeling of soticlestat, a novel cholesterol 24‐hydroxylase inhibitor, in healthy adults
por: Yin, Wei, et al.
Publicado: (2023)

The social and ethical issues of online learning during the pandemic and beyond
por: Bhattacharya, Sonali, et al.
Publicado: (2022)

Did people really drink bleach to prevent COVID-19? A guide for protecting survey data against problematic respondents
por: Litman, Leib, et al.
Publicado: (2023)

The Nucleus Accumbens: A Switchboard for Goal-Directed Behaviors
por: Gruber, Aaron J., et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_jpmp0ci376nc3qrk5ed4qe6sek