Total synthesis of bi-magnolignan

Bi-magnolignan, isolated from the leaves of Magnolia officinalis, has shown excellent physiological activity against tumor cells. An efficient strategy for the first total synthesis of bi-magnolignan is reported. The bi-dibenzofuran skeleton was constructed via functional group interconversions of c...

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Detalles Bibliográficos
Autores principales: Lu, Si-Yuan, Wang, Hong-Mei, Feng, Na, Ma, Ai-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018648/
https://www.ncbi.nlm.nih.gov/pubmed/36936845
http://dx.doi.org/10.1039/d3ra01121f
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author Lu, Si-Yuan
Wang, Hong-Mei
Feng, Na
Ma, Ai-Jun
author_facet Lu, Si-Yuan
Wang, Hong-Mei
Feng, Na
Ma, Ai-Jun
author_sort Lu, Si-Yuan
collection PubMed
description Bi-magnolignan, isolated from the leaves of Magnolia officinalis, has shown excellent physiological activity against tumor cells. An efficient strategy for the first total synthesis of bi-magnolignan is reported. The bi-dibenzofuran skeleton was constructed via functional group interconversions of commercially available materials 1,2,4-trimethoxybenzene and 4-allylanisole. Then, the dibenzofuran skeleton was afforded by subsequent Suzuki coupling and intramolecular dehydration. The total synthesis of natural product was accomplished through FeCl(3) catalyzed oxidative coupling.
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spelling pubmed-100186482023-03-17 Total synthesis of bi-magnolignan Lu, Si-Yuan Wang, Hong-Mei Feng, Na Ma, Ai-Jun RSC Adv Chemistry Bi-magnolignan, isolated from the leaves of Magnolia officinalis, has shown excellent physiological activity against tumor cells. An efficient strategy for the first total synthesis of bi-magnolignan is reported. The bi-dibenzofuran skeleton was constructed via functional group interconversions of commercially available materials 1,2,4-trimethoxybenzene and 4-allylanisole. Then, the dibenzofuran skeleton was afforded by subsequent Suzuki coupling and intramolecular dehydration. The total synthesis of natural product was accomplished through FeCl(3) catalyzed oxidative coupling. The Royal Society of Chemistry 2023-03-16 /pmc/articles/PMC10018648/ /pubmed/36936845 http://dx.doi.org/10.1039/d3ra01121f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Lu, Si-Yuan
Wang, Hong-Mei
Feng, Na
Ma, Ai-Jun
Total synthesis of bi-magnolignan
title Total synthesis of bi-magnolignan
title_full Total synthesis of bi-magnolignan
title_fullStr Total synthesis of bi-magnolignan
title_full_unstemmed Total synthesis of bi-magnolignan
title_short Total synthesis of bi-magnolignan
title_sort total synthesis of bi-magnolignan
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018648/
https://www.ncbi.nlm.nih.gov/pubmed/36936845
http://dx.doi.org/10.1039/d3ra01121f
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