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Disulfide Bridged Nanoparticles of Thiolated Sodium Alginate and Eudragit RS100 for Oral Delivery of Paclitaxel: In Vitro and In Vivo Evaluation
[Image: see text] Most biopharmaceutics classification system (BCS) class IV drugs have limited oral bioavailability due to poor solubility and poorer permeability. This work aims to investigate the possibility of utilizing disulfide bridged nanoparticles to improve BCS IV drug solubility and oral a...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018692/ https://www.ncbi.nlm.nih.gov/pubmed/36936332 http://dx.doi.org/10.1021/acsomega.3c00400 |
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author | Khalid, Hafiz Muhammad Bilal Rasul, Akhtar Shah, Shahid Abbas, Ghulam Mahmood, Abid |
author_facet | Khalid, Hafiz Muhammad Bilal Rasul, Akhtar Shah, Shahid Abbas, Ghulam Mahmood, Abid |
author_sort | Khalid, Hafiz Muhammad Bilal |
collection | PubMed |
description | [Image: see text] Most biopharmaceutics classification system (BCS) class IV drugs have limited oral bioavailability due to poor solubility and poorer permeability. This work aims to investigate the possibility of utilizing disulfide bridged nanoparticles to improve BCS IV drug solubility and oral absorption. Disulfide bridged nanoparticles were made using thiolated sodium alginate (TSA) and thiolated eudragit RS100 (TERS100). This study used paclitaxel (PTL) as a model drug to create PTL-loaded nanoparticles using the air oxidation approach. PTL-loaded nanoparticles boosted the solubility of PTL by over 11 times (∼59 μg/mL). The nanoparticles had particle sizes of 103 nm, polydispersity indices of 0.034, and zeta potentials of −21 mV, respectively. Nanoparticles demonstrated 75.34% and 89.18% entrapment and loading efficiency of PTL, respectively. The PTL release data from nanoparticles had good sustained release properties. The effective permeability of PTL from nanoparticles was 2.19-fold higher than that of pure PTL suspension. The relative bioavailability of PTL with disulfide bridged nanoparticles was 237.11%, which was much higher than that of PTL suspension, according to the pharmacokinetic data. These results show that disulfide bridged nanoparticles have a wide range of clinical applications. |
format | Online Article Text |
id | pubmed-10018692 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-100186922023-03-17 Disulfide Bridged Nanoparticles of Thiolated Sodium Alginate and Eudragit RS100 for Oral Delivery of Paclitaxel: In Vitro and In Vivo Evaluation Khalid, Hafiz Muhammad Bilal Rasul, Akhtar Shah, Shahid Abbas, Ghulam Mahmood, Abid ACS Omega [Image: see text] Most biopharmaceutics classification system (BCS) class IV drugs have limited oral bioavailability due to poor solubility and poorer permeability. This work aims to investigate the possibility of utilizing disulfide bridged nanoparticles to improve BCS IV drug solubility and oral absorption. Disulfide bridged nanoparticles were made using thiolated sodium alginate (TSA) and thiolated eudragit RS100 (TERS100). This study used paclitaxel (PTL) as a model drug to create PTL-loaded nanoparticles using the air oxidation approach. PTL-loaded nanoparticles boosted the solubility of PTL by over 11 times (∼59 μg/mL). The nanoparticles had particle sizes of 103 nm, polydispersity indices of 0.034, and zeta potentials of −21 mV, respectively. Nanoparticles demonstrated 75.34% and 89.18% entrapment and loading efficiency of PTL, respectively. The PTL release data from nanoparticles had good sustained release properties. The effective permeability of PTL from nanoparticles was 2.19-fold higher than that of pure PTL suspension. The relative bioavailability of PTL with disulfide bridged nanoparticles was 237.11%, which was much higher than that of PTL suspension, according to the pharmacokinetic data. These results show that disulfide bridged nanoparticles have a wide range of clinical applications. American Chemical Society 2023-03-03 /pmc/articles/PMC10018692/ /pubmed/36936332 http://dx.doi.org/10.1021/acsomega.3c00400 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Khalid, Hafiz Muhammad Bilal Rasul, Akhtar Shah, Shahid Abbas, Ghulam Mahmood, Abid Disulfide Bridged Nanoparticles of Thiolated Sodium Alginate and Eudragit RS100 for Oral Delivery of Paclitaxel: In Vitro and In Vivo Evaluation |
title | Disulfide Bridged
Nanoparticles of Thiolated Sodium
Alginate and Eudragit RS100 for Oral Delivery of Paclitaxel: In Vitro and In Vivo Evaluation |
title_full | Disulfide Bridged
Nanoparticles of Thiolated Sodium
Alginate and Eudragit RS100 for Oral Delivery of Paclitaxel: In Vitro and In Vivo Evaluation |
title_fullStr | Disulfide Bridged
Nanoparticles of Thiolated Sodium
Alginate and Eudragit RS100 for Oral Delivery of Paclitaxel: In Vitro and In Vivo Evaluation |
title_full_unstemmed | Disulfide Bridged
Nanoparticles of Thiolated Sodium
Alginate and Eudragit RS100 for Oral Delivery of Paclitaxel: In Vitro and In Vivo Evaluation |
title_short | Disulfide Bridged
Nanoparticles of Thiolated Sodium
Alginate and Eudragit RS100 for Oral Delivery of Paclitaxel: In Vitro and In Vivo Evaluation |
title_sort | disulfide bridged
nanoparticles of thiolated sodium
alginate and eudragit rs100 for oral delivery of paclitaxel: in vitro and in vivo evaluation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018692/ https://www.ncbi.nlm.nih.gov/pubmed/36936332 http://dx.doi.org/10.1021/acsomega.3c00400 |
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