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Accessing Chiral Pyrrolodiketopiperazines under Organocatalytic Conditions
[Image: see text] The production of chiral pyrrolodiketopiperazines under organocatalytic conditions demonstrates the capacity of bicyclic acylpyrrol lactims to perform as pronucleophiles in direct carbon–carbon bond forming reactions. The good performance of ureidoaminal-derived Brønsted bases in t...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018776/ https://www.ncbi.nlm.nih.gov/pubmed/36579971 http://dx.doi.org/10.1021/acs.orglett.2c03924 |
| Sumario: | [Image: see text] The production of chiral pyrrolodiketopiperazines under organocatalytic conditions demonstrates the capacity of bicyclic acylpyrrol lactims to perform as pronucleophiles in direct carbon–carbon bond forming reactions. The good performance of ureidoaminal-derived Brønsted bases in the Michael addition to nitroolefins affords these heterocyclic scaffolds with high skeleton diversity. |
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