Accessing Chiral Pyrrolodiketopiperazines under Organocatalytic Conditions

[Image: see text] The production of chiral pyrrolodiketopiperazines under organocatalytic conditions demonstrates the capacity of bicyclic acylpyrrol lactims to perform as pronucleophiles in direct carbon–carbon bond forming reactions. The good performance of ureidoaminal-derived Brønsted bases in t...

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Autores principales: Duñabeitia, Eider, Landa, Aitor, López, Rosa, Palomo, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018776/
https://www.ncbi.nlm.nih.gov/pubmed/36579971
http://dx.doi.org/10.1021/acs.orglett.2c03924
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author Duñabeitia, Eider
Landa, Aitor
López, Rosa
Palomo, Claudio
author_facet Duñabeitia, Eider
Landa, Aitor
López, Rosa
Palomo, Claudio
author_sort Duñabeitia, Eider
collection PubMed
description [Image: see text] The production of chiral pyrrolodiketopiperazines under organocatalytic conditions demonstrates the capacity of bicyclic acylpyrrol lactims to perform as pronucleophiles in direct carbon–carbon bond forming reactions. The good performance of ureidoaminal-derived Brønsted bases in the Michael addition to nitroolefins affords these heterocyclic scaffolds with high skeleton diversity.
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spelling pubmed-100187762023-03-17 Accessing Chiral Pyrrolodiketopiperazines under Organocatalytic Conditions Duñabeitia, Eider Landa, Aitor López, Rosa Palomo, Claudio Org Lett [Image: see text] The production of chiral pyrrolodiketopiperazines under organocatalytic conditions demonstrates the capacity of bicyclic acylpyrrol lactims to perform as pronucleophiles in direct carbon–carbon bond forming reactions. The good performance of ureidoaminal-derived Brønsted bases in the Michael addition to nitroolefins affords these heterocyclic scaffolds with high skeleton diversity. American Chemical Society 2022-12-29 /pmc/articles/PMC10018776/ /pubmed/36579971 http://dx.doi.org/10.1021/acs.orglett.2c03924 Text en © 2022 American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Duñabeitia, Eider
Landa, Aitor
López, Rosa
Palomo, Claudio
Accessing Chiral Pyrrolodiketopiperazines under Organocatalytic Conditions
title Accessing Chiral Pyrrolodiketopiperazines under Organocatalytic Conditions
title_full Accessing Chiral Pyrrolodiketopiperazines under Organocatalytic Conditions
title_fullStr Accessing Chiral Pyrrolodiketopiperazines under Organocatalytic Conditions
title_full_unstemmed Accessing Chiral Pyrrolodiketopiperazines under Organocatalytic Conditions
title_short Accessing Chiral Pyrrolodiketopiperazines under Organocatalytic Conditions
title_sort accessing chiral pyrrolodiketopiperazines under organocatalytic conditions
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018776/
https://www.ncbi.nlm.nih.gov/pubmed/36579971
http://dx.doi.org/10.1021/acs.orglett.2c03924
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