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Activation of STAT3 through combined SRC and EGFR signaling drives resistance to a mitotic kinesin inhibitor in glioblastoma

Inhibitors of the mitotic kinesin Kif11 are anti-mitotics that, unlike vinca alkaloids or taxanes, do not disrupt microtubules and are not neurotoxic. However, development of resistance has limited their clinical utility. While resistance to Kif11 inhibitors in other cell types is due to mechanisms...

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Detalles Bibliográficos
Autores principales:	Kenchappa, Rajappa S., Dovas, Athanassios, Argenziano, Michael G., Meyer, Christian T., Stopfer, Lauren E., Banu, Matei A., Pereira, Brianna, Griffith, Jessica, Mohammad, Afroz, Talele, Surabhi, Haddock, Ashley, Zarco, Natanael, Elmquist, William, White, Forest, Quaranta, Vito, Sims, Peter, Canoll, Peter, Rosenfeld, Steven S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018805/ https://www.ncbi.nlm.nih.gov/pubmed/35732128 http://dx.doi.org/10.1016/j.celrep.2022.110991

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