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Improving the production of 9α-hydroxy-4-androstene-3,17-dione from phytosterols by 3-ketosteroid-Δ(1)-dehydrogenase deletions and multiple genetic modifications in Mycobacterium fortuitum

BACKGROUND: 9α-hydroxyandrost-4-ene-3,17-dione (9-OHAD) is a significant intermediate for the synthesis of glucocorticoid drugs. However, in the process of phytosterol biotransformation to manufacture 9-OHAD, product degradation, and by-products restrict 9-OHAD output. In this study, to construct a...

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Detalles Bibliográficos
Autores principales:	Liu, Xiangcen, Zhang, Jingxian, Yuan, Chenyang, Du, Guilin, Han, Suwan, Shi, Jiping, Sun, Junsong, Zhang, Baoguo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018825/ https://www.ncbi.nlm.nih.gov/pubmed/36922830 http://dx.doi.org/10.1186/s12934-023-02052-y

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