Increased circulating uric acid aggravates heart failure via impaired fatty acid metabolism

BACKGROUND: Increased circulating uric acid (UA) concentration may disrupt cardiac function in heart failure patients, but the specific mechanism remains unclear. Here, we postulate that hyperuremia induces sterol regulatory element binding protein 1 (SREBP1), which in turn activate hepatic fatty ac...

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Detalles Bibliográficos
Autores principales: Lou, Bowen, Wu, Haoyu, Ott, Hannes, Bennewitz, Katrin, Wang, Chen, Poschet, Gernot, Liu, Hui, Yuan, Zuyi, Kroll, Jens, She, Jianqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018852/
https://www.ncbi.nlm.nih.gov/pubmed/36927819
http://dx.doi.org/10.1186/s12967-023-04050-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018852/
https://www.ncbi.nlm.nih.gov/pubmed/36927819
http://dx.doi.org/10.1186/s12967-023-04050-5

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