Cargando…

Increased circulating uric acid aggravates heart failure via impaired fatty acid metabolism

BACKGROUND: Increased circulating uric acid (UA) concentration may disrupt cardiac function in heart failure patients, but the specific mechanism remains unclear. Here, we postulate that hyperuremia induces sterol regulatory element binding protein 1 (SREBP1), which in turn activate hepatic fatty ac...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lou, Bowen, Wu, Haoyu, Ott, Hannes, Bennewitz, Katrin, Wang, Chen, Poschet, Gernot, Liu, Hui, Yuan, Zuyi, Kroll, Jens, She, Jianqing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018852/ https://www.ncbi.nlm.nih.gov/pubmed/36927819 http://dx.doi.org/10.1186/s12967-023-04050-5

Ejemplares similares

Metabolic and Transcriptional Adaptations Improve Physical Performance of Zebrafish
por: Heinkele, Franziska J., et al.
Publicado: (2021)

Acrolein-inducing ferroptosis contributes to impaired peripheral neurogenesis in zebrafish
por: Qi, Haozhe, et al.
Publicado: (2023)

Interplay Between Gut Microbiota and Amino Acid Metabolism in Heart Failure
por: Tuerhongjiang, Gulinigaer, et al.
Publicado: (2021)

Comparative Morphological, Metabolic and Transcriptome Analyses in elmo1 ( −/− ), elmo2 ( −/− ), and elmo3 ( −/− ) Zebrafish Mutants Identified a Functional Non-Redundancy of the Elmo Proteins
por: Boger, Mike, et al.
Publicado: (2022)

Circulating lipid and lipoprotein profiles and their correlation to cardiac function and cardiovascular outcomes in patients with acute myocardial infarction
por: Wu, Haoyu, et al.
Publicado: (2021)

Loss of glyoxalase 2 alters the glucose metabolism in zebrafish
por: Tabler, Christoph Tobias, et al.
Publicado: (2022)

Uric Acid as the Cause of Gout and Gouty Circulation
por: Haig, Alexander
Publicado: (1906)

Targeting erythropoietin protects against proteinuria in type 2 diabetic patients and in zebrafish
por: She, Jianqing, et al.
Publicado: (2017)

Elevated 4-hydroxynonenal induces hyperglycaemia via Aldh3a1 loss in zebrafish and associates with diabetes progression in humans
por: Lou, Bowen, et al.
Publicado: (2020)

ARNI versus ACEI/ARB in Reducing Cardiovascular Outcomes after Myocardial Infarction
por: She, Jianqing, et al.
Publicado: (2021)

Folic acid reverses uric acid crystal-induced surface OAT1 internalization by inhibiting RhoA activity in uric acid nephropathy
por: WU, XINLIN, et al.
Publicado: (2016)

Uric Acid
Publicado: (1900)

Uric Acid
Publicado: (1898)

Targeting amino acids metabolic profile to identify novel metabolic characteristics in atrial fibrillation
por: She, Jianqing, et al.
Publicado: (2018)

Organochloride pesticides impaired mitochondrial function in hepatocytes and aggravated disorders of fatty acid metabolism
por: Liu, Qian, et al.
Publicado: (2017)

Obesity-Related Gut Microbiota Aggravates Alveolar Bone Destruction in Experimental Periodontitis through Elevation of Uric Acid
por: Sato, Keisuke, et al.
Publicado: (2021)

Impact of Age, Sex, and Renal Function on the Efficacy and Safety of Direct Oral Anticoagulants vs. Vitamin K Antagonists for the Treatment of Acute Venous Thromboembolism: A Meta-Analysis of 22,040 Patients
por: Zhou, Bo, et al.
Publicado: (2021)

Regulation of Gluconeogenesis by Aldo-keto-reductase 1a1b in Zebrafish
por: Li, Xiaogang, et al.
Publicado: (2020)

Deep Metabolic Profiling Assessment of Tissue Extraction Protocols for Three Model Organisms
por: Gegner, Hagen M., et al.
Publicado: (2022)

Association of Serum Uric Acid Levels in Meige’s Syndrome
por: Guan, Haochen, et al.
Publicado: (2021)

Uric Acid and the Heart
Publicado: (2005)

Dissertation on the Uric Acid
Publicado: (1808)

Injection of Uric Acid
Publicado: (1873)

Uric Acid Toxaemia
por: Dixon, Arch
Publicado: (1900)

Association between Cystatin C and Cardiac Function in Acute Myocardial Infarction Patients: A Real-World Analysis
por: Lou, Bowen, et al.
Publicado: (2022)

In-hospital initiation of PCSK9 inhibitor and short-term lipid control in patients with acute myocardial infarction
por: Lou, Bowen, et al.
Publicado: (2022)

High uric acid or low uric acid which is better for hemodialysis patients?
por: Wang, Wenyun, et al.
Publicado: (2020)

The Relationship between Normal Serum Uric Acid and Nonalcoholic Fatty Liver Disease
por: Hwang, In-Cheol, et al.
Publicado: (2011)

Uric Acid Stimulates Fructokinase and Accelerates Fructose Metabolism in the Development of Fatty Liver
por: Lanaspa, Miguel A., et al.
Publicado: (2012)

Combined effect of obesity and uric acid on nonalcoholic fatty liver disease and hypertriglyceridemia
por: Zhang, Shujun, et al.
Publicado: (2017)

Level of uric acid and uric acid/creatinine ratios in correlation with stage of Parkinson disease
por: Zhong, Ling-Ling, et al.
Publicado: (2018)

Uric acid transporters BCRP and MRP4 involved in chickens uric acid excretion
por: Ding, Xuedong, et al.
Publicado: (2019)

The effect of dapagliflozin on uric acid excretion and serum uric acid level in advanced CKD
por: Iwata, Yukimasa, et al.
Publicado: (2023)

Fatty Acid-Binding Proteins Aggravate Cerebral Ischemia-Reperfusion Injury in Mice
por: Guo, Qingyun, et al.
Publicado: (2021)

Influence of Salicylic Acid on the Excretion of Uric Acid
Publicado: (1889)

Inhibition of fatty acid oxidation enables heart regeneration in adult mice
por: Li, Xiang, et al.
Publicado: (2023)

Clinical Values of Serum Uric Acid Levels in the Occurrence of Cognitive Impairment in Alcohol-Dependent Patients
por: Bai, Jinglin, et al.
Publicado: (2023)

URIC ACID AND TISSUE REPAIR
por: NERY, Rodrigo Araldi, et al.
Publicado: (2015)

The Treatment of Uric-Acid Gravel
Publicado: (1901)

The Treatment of the Uric Acid Diathesis
por: Lucas, John C.
Publicado: (1882)

Cannot write session to /tmp/vufind_sessions/sess_8i6kmt414tmhc7e2r1gtrri8bn