Loss of MBNL1-mediated retrograde BDNF signaling in the myotonic dystrophy brain

Reduced brain volume including atrophy in grey and white matter is commonly seen in myotonic dystrophy type 1 (DM1). DM1 is caused by an expansion of CTG trinucleotide repeats in the 3’ untranslated region (UTR) of the Dystrophia Myotonica Protein Kinase (DMPK) gene. Mutant DMPK mRNA containing expa...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Pei-Ying, Kuo, Ting-Yu, Wang, Lee-Hsin, Liang, Wen-Hsing, Wang, Guey-Shin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018927/
https://www.ncbi.nlm.nih.gov/pubmed/36922901
http://dx.doi.org/10.1186/s40478-023-01540-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018927/
https://www.ncbi.nlm.nih.gov/pubmed/36922901
http://dx.doi.org/10.1186/s40478-023-01540-x

Ejemplares similares