Different outcomes following parathyroidectomy in patients with uremic tumoral calcinosis: two case reports

BACKGROUND: Uremic tumoral calcinosis (UTC) is a rare complication in hemodialysis patients, whose mechanism remains incompletely understood. We report two cases with UTC who experienced completely different patterns of regression following parathyroidectomy, although there were no significant diffe...

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Autores principales: Li, Jialin, Li, Xuan, Dong, Xiuhong, Ma, Lin, Guo, Zhentao, Chen, Xuexun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018971/
https://www.ncbi.nlm.nih.gov/pubmed/36922797
http://dx.doi.org/10.1186/s12882-023-03107-3
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author Li, Jialin
Li, Xuan
Dong, Xiuhong
Ma, Lin
Guo, Zhentao
Chen, Xuexun
author_facet Li, Jialin
Li, Xuan
Dong, Xiuhong
Ma, Lin
Guo, Zhentao
Chen, Xuexun
author_sort Li, Jialin
collection PubMed
description BACKGROUND: Uremic tumoral calcinosis (UTC) is a rare complication in hemodialysis patients, whose mechanism remains incompletely understood. We report two cases with UTC who experienced completely different patterns of regression following parathyroidectomy, although there were no significant differences in serum calcium levels, parathyroid hormone, or phosphorus production between the two patients. CASE PRESENTATION: Case 1 had a substantial improvement in soft tissue calcification. However, in Case 2, one calcified mass was partially absorbed, while the others were aggravated with severe microvascular calcification and subcutaneous extravascular calcification. Whole-exome sequencing data revealed five mutation sites associated with atherosclerosis. CONCLUSION: The different outcomes in UTC patients after PTX are rare. Further studies are required to elucidate the mechanism of paradoxical changes occurring in patients with UTC after parathyroidectomy.
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spelling pubmed-100189712023-03-17 Different outcomes following parathyroidectomy in patients with uremic tumoral calcinosis: two case reports Li, Jialin Li, Xuan Dong, Xiuhong Ma, Lin Guo, Zhentao Chen, Xuexun BMC Nephrol Case Report BACKGROUND: Uremic tumoral calcinosis (UTC) is a rare complication in hemodialysis patients, whose mechanism remains incompletely understood. We report two cases with UTC who experienced completely different patterns of regression following parathyroidectomy, although there were no significant differences in serum calcium levels, parathyroid hormone, or phosphorus production between the two patients. CASE PRESENTATION: Case 1 had a substantial improvement in soft tissue calcification. However, in Case 2, one calcified mass was partially absorbed, while the others were aggravated with severe microvascular calcification and subcutaneous extravascular calcification. Whole-exome sequencing data revealed five mutation sites associated with atherosclerosis. CONCLUSION: The different outcomes in UTC patients after PTX are rare. Further studies are required to elucidate the mechanism of paradoxical changes occurring in patients with UTC after parathyroidectomy. BioMed Central 2023-03-15 /pmc/articles/PMC10018971/ /pubmed/36922797 http://dx.doi.org/10.1186/s12882-023-03107-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Li, Jialin
Li, Xuan
Dong, Xiuhong
Ma, Lin
Guo, Zhentao
Chen, Xuexun
Different outcomes following parathyroidectomy in patients with uremic tumoral calcinosis: two case reports
title Different outcomes following parathyroidectomy in patients with uremic tumoral calcinosis: two case reports
title_full Different outcomes following parathyroidectomy in patients with uremic tumoral calcinosis: two case reports
title_fullStr Different outcomes following parathyroidectomy in patients with uremic tumoral calcinosis: two case reports
title_full_unstemmed Different outcomes following parathyroidectomy in patients with uremic tumoral calcinosis: two case reports
title_short Different outcomes following parathyroidectomy in patients with uremic tumoral calcinosis: two case reports
title_sort different outcomes following parathyroidectomy in patients with uremic tumoral calcinosis: two case reports
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018971/
https://www.ncbi.nlm.nih.gov/pubmed/36922797
http://dx.doi.org/10.1186/s12882-023-03107-3
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