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Detection of antibodies to SARS-CoV-2 after vaccination in seminal plasma and their association to sperm parameters
There is a public concern that COVID-19 vaccination and SARS-CoV-2 antibodies (Abs) negatively affect male fertility. However, the evidence for the presence of SARS-CoV-2 Abs in seminal plasma (SP) is lacking. We examined whether Abs were detectable in SP after COVID-19 vaccination in 86 men using a...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019047/ https://www.ncbi.nlm.nih.gov/pubmed/36933610 http://dx.doi.org/10.1016/j.ijid.2023.03.018 |
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author | Chillon, Thilo Samson Demircan, Kamil Weiss, Gregor Minich, Waldemar B. Schenk, Michael Schomburg, Lutz |
author_facet | Chillon, Thilo Samson Demircan, Kamil Weiss, Gregor Minich, Waldemar B. Schenk, Michael Schomburg, Lutz |
author_sort | Chillon, Thilo Samson |
collection | PubMed |
description | There is a public concern that COVID-19 vaccination and SARS-CoV-2 antibodies (Abs) negatively affect male fertility. However, the evidence for the presence of SARS-CoV-2 Abs in seminal plasma (SP) is lacking. We examined whether Abs were detectable in SP after COVID-19 vaccination in 86 men using a direct Ab measurement and by quantification of their neutralizing activity. The results show the presence of SARS-CoV-2 Abs in SP, with a strong correlation to the serum Abs, increasing with the number of vaccinations. Furthermore, the Ab titers are correlating with the neutralization activity. The SARS-CoV-2 vaccination parameters showed no association with the markers of sperm quality. In conclusion, this study indicates substantial levels of Abs in SP after COVID-19 vaccination that correlate with serum Ab titers but do not associate with sperm quality. |
format | Online Article Text |
id | pubmed-10019047 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100190472023-03-16 Detection of antibodies to SARS-CoV-2 after vaccination in seminal plasma and their association to sperm parameters Chillon, Thilo Samson Demircan, Kamil Weiss, Gregor Minich, Waldemar B. Schenk, Michael Schomburg, Lutz Int J Infect Dis Short Communication There is a public concern that COVID-19 vaccination and SARS-CoV-2 antibodies (Abs) negatively affect male fertility. However, the evidence for the presence of SARS-CoV-2 Abs in seminal plasma (SP) is lacking. We examined whether Abs were detectable in SP after COVID-19 vaccination in 86 men using a direct Ab measurement and by quantification of their neutralizing activity. The results show the presence of SARS-CoV-2 Abs in SP, with a strong correlation to the serum Abs, increasing with the number of vaccinations. Furthermore, the Ab titers are correlating with the neutralization activity. The SARS-CoV-2 vaccination parameters showed no association with the markers of sperm quality. In conclusion, this study indicates substantial levels of Abs in SP after COVID-19 vaccination that correlate with serum Ab titers but do not associate with sperm quality. The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2023-05 2023-03-16 /pmc/articles/PMC10019047/ /pubmed/36933610 http://dx.doi.org/10.1016/j.ijid.2023.03.018 Text en © 2023 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Short Communication Chillon, Thilo Samson Demircan, Kamil Weiss, Gregor Minich, Waldemar B. Schenk, Michael Schomburg, Lutz Detection of antibodies to SARS-CoV-2 after vaccination in seminal plasma and their association to sperm parameters |
title | Detection of antibodies to SARS-CoV-2 after vaccination in seminal plasma and their association to sperm parameters |
title_full | Detection of antibodies to SARS-CoV-2 after vaccination in seminal plasma and their association to sperm parameters |
title_fullStr | Detection of antibodies to SARS-CoV-2 after vaccination in seminal plasma and their association to sperm parameters |
title_full_unstemmed | Detection of antibodies to SARS-CoV-2 after vaccination in seminal plasma and their association to sperm parameters |
title_short | Detection of antibodies to SARS-CoV-2 after vaccination in seminal plasma and their association to sperm parameters |
title_sort | detection of antibodies to sars-cov-2 after vaccination in seminal plasma and their association to sperm parameters |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019047/ https://www.ncbi.nlm.nih.gov/pubmed/36933610 http://dx.doi.org/10.1016/j.ijid.2023.03.018 |
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