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Detection of antibodies to SARS-CoV-2 after vaccination in seminal plasma and their association to sperm parameters

There is a public concern that COVID-19 vaccination and SARS-CoV-2 antibodies (Abs) negatively affect male fertility. However, the evidence for the presence of SARS-CoV-2 Abs in seminal plasma (SP) is lacking. We examined whether Abs were detectable in SP after COVID-19 vaccination in 86 men using a...

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Autores principales: Chillon, Thilo Samson, Demircan, Kamil, Weiss, Gregor, Minich, Waldemar B., Schenk, Michael, Schomburg, Lutz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019047/
https://www.ncbi.nlm.nih.gov/pubmed/36933610
http://dx.doi.org/10.1016/j.ijid.2023.03.018
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author Chillon, Thilo Samson
Demircan, Kamil
Weiss, Gregor
Minich, Waldemar B.
Schenk, Michael
Schomburg, Lutz
author_facet Chillon, Thilo Samson
Demircan, Kamil
Weiss, Gregor
Minich, Waldemar B.
Schenk, Michael
Schomburg, Lutz
author_sort Chillon, Thilo Samson
collection PubMed
description There is a public concern that COVID-19 vaccination and SARS-CoV-2 antibodies (Abs) negatively affect male fertility. However, the evidence for the presence of SARS-CoV-2 Abs in seminal plasma (SP) is lacking. We examined whether Abs were detectable in SP after COVID-19 vaccination in 86 men using a direct Ab measurement and by quantification of their neutralizing activity. The results show the presence of SARS-CoV-2 Abs in SP, with a strong correlation to the serum Abs, increasing with the number of vaccinations. Furthermore, the Ab titers are correlating with the neutralization activity. The SARS-CoV-2 vaccination parameters showed no association with the markers of sperm quality. In conclusion, this study indicates substantial levels of Abs in SP after COVID-19 vaccination that correlate with serum Ab titers but do not associate with sperm quality.
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spelling pubmed-100190472023-03-16 Detection of antibodies to SARS-CoV-2 after vaccination in seminal plasma and their association to sperm parameters Chillon, Thilo Samson Demircan, Kamil Weiss, Gregor Minich, Waldemar B. Schenk, Michael Schomburg, Lutz Int J Infect Dis Short Communication There is a public concern that COVID-19 vaccination and SARS-CoV-2 antibodies (Abs) negatively affect male fertility. However, the evidence for the presence of SARS-CoV-2 Abs in seminal plasma (SP) is lacking. We examined whether Abs were detectable in SP after COVID-19 vaccination in 86 men using a direct Ab measurement and by quantification of their neutralizing activity. The results show the presence of SARS-CoV-2 Abs in SP, with a strong correlation to the serum Abs, increasing with the number of vaccinations. Furthermore, the Ab titers are correlating with the neutralization activity. The SARS-CoV-2 vaccination parameters showed no association with the markers of sperm quality. In conclusion, this study indicates substantial levels of Abs in SP after COVID-19 vaccination that correlate with serum Ab titers but do not associate with sperm quality. The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2023-05 2023-03-16 /pmc/articles/PMC10019047/ /pubmed/36933610 http://dx.doi.org/10.1016/j.ijid.2023.03.018 Text en © 2023 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Short Communication
Chillon, Thilo Samson
Demircan, Kamil
Weiss, Gregor
Minich, Waldemar B.
Schenk, Michael
Schomburg, Lutz
Detection of antibodies to SARS-CoV-2 after vaccination in seminal plasma and their association to sperm parameters
title Detection of antibodies to SARS-CoV-2 after vaccination in seminal plasma and their association to sperm parameters
title_full Detection of antibodies to SARS-CoV-2 after vaccination in seminal plasma and their association to sperm parameters
title_fullStr Detection of antibodies to SARS-CoV-2 after vaccination in seminal plasma and their association to sperm parameters
title_full_unstemmed Detection of antibodies to SARS-CoV-2 after vaccination in seminal plasma and their association to sperm parameters
title_short Detection of antibodies to SARS-CoV-2 after vaccination in seminal plasma and their association to sperm parameters
title_sort detection of antibodies to sars-cov-2 after vaccination in seminal plasma and their association to sperm parameters
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019047/
https://www.ncbi.nlm.nih.gov/pubmed/36933610
http://dx.doi.org/10.1016/j.ijid.2023.03.018
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