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Neutrophil to lymphocyte ratio can predict overall survival in patients with stage II to III colorectal cancer
The neutrophil-to-lymphocyte ratio (NLR) is a prognostic inflammatory marker in colorectal cancer (CRC), however, little is known for its prognostic role in stage II to III CRC patients underwent curative resection. This study was aimed to investigate prognostic role of NLR in stage II to III CRC pa...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019177/ https://www.ncbi.nlm.nih.gov/pubmed/36930098 http://dx.doi.org/10.1097/MD.0000000000033279 |
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author | Cho, Yerim Park, Su Bee Yoon, Jin Young Kwak, Min Seob Cha, Jae Myung |
author_facet | Cho, Yerim Park, Su Bee Yoon, Jin Young Kwak, Min Seob Cha, Jae Myung |
author_sort | Cho, Yerim |
collection | PubMed |
description | The neutrophil-to-lymphocyte ratio (NLR) is a prognostic inflammatory marker in colorectal cancer (CRC), however, little is known for its prognostic role in stage II to III CRC patients underwent curative resection. This study was aimed to investigate prognostic role of NLR in stage II to III CRC patients underwent surgery. Medical records of 1378 newly diagnosed CRC patients between June 2006 and March 2020 were reviewed. Data were collected by using electronic medical record software. Survival rate were analyzed using the Kaplan–Meier method. The cutoff values of NLR in stage II to III CRC patients were defined by maximally selected log-rank statistics. Multivariable cox proportional-hazard models were performed to find risk factors associated with overall survival (OS) in stage II to III CRC patients underwent surgery. Among 1378 CRC patients enrolled, 910 patients underwent surgery. In entire surgical cohort, age, body mass index (BMI), CEA, carbohydrate antigen 19-9 (CA 19-9), lymphatic invasion, NLR, and albumin-to-globulin ratio (AGR) were found to be risk factors associated with OS (all P < .05). In stage II to III CRC patients underwent curative resection (n = 623), age, BMI, lymphatic invasion, AGR, and NLR were found to be risk factors associated with OS (all P < .05). In the multivariable analysis, CA 19-9 and lymphatic invasion were independent risk factors for OS in entire surgical cohort. In the multivariable analysis for the stage II to III CRC patients, age, BMI, lymphatic invasion and NLR (Hazard ratio = 2.41, 95% confidential interval [CI]: 1.04–5.595, P = .041) were independent risk factors for OS. NLR can be used as a clinically simple and useful parameter for predicting OS in stage II to III CRC patients undergoing curative resection, however, its optimal cutoff value should be further evaluated. |
format | Online Article Text |
id | pubmed-10019177 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-100191772023-03-17 Neutrophil to lymphocyte ratio can predict overall survival in patients with stage II to III colorectal cancer Cho, Yerim Park, Su Bee Yoon, Jin Young Kwak, Min Seob Cha, Jae Myung Medicine (Baltimore) 4500 The neutrophil-to-lymphocyte ratio (NLR) is a prognostic inflammatory marker in colorectal cancer (CRC), however, little is known for its prognostic role in stage II to III CRC patients underwent curative resection. This study was aimed to investigate prognostic role of NLR in stage II to III CRC patients underwent surgery. Medical records of 1378 newly diagnosed CRC patients between June 2006 and March 2020 were reviewed. Data were collected by using electronic medical record software. Survival rate were analyzed using the Kaplan–Meier method. The cutoff values of NLR in stage II to III CRC patients were defined by maximally selected log-rank statistics. Multivariable cox proportional-hazard models were performed to find risk factors associated with overall survival (OS) in stage II to III CRC patients underwent surgery. Among 1378 CRC patients enrolled, 910 patients underwent surgery. In entire surgical cohort, age, body mass index (BMI), CEA, carbohydrate antigen 19-9 (CA 19-9), lymphatic invasion, NLR, and albumin-to-globulin ratio (AGR) were found to be risk factors associated with OS (all P < .05). In stage II to III CRC patients underwent curative resection (n = 623), age, BMI, lymphatic invasion, AGR, and NLR were found to be risk factors associated with OS (all P < .05). In the multivariable analysis, CA 19-9 and lymphatic invasion were independent risk factors for OS in entire surgical cohort. In the multivariable analysis for the stage II to III CRC patients, age, BMI, lymphatic invasion and NLR (Hazard ratio = 2.41, 95% confidential interval [CI]: 1.04–5.595, P = .041) were independent risk factors for OS. NLR can be used as a clinically simple and useful parameter for predicting OS in stage II to III CRC patients undergoing curative resection, however, its optimal cutoff value should be further evaluated. Lippincott Williams & Wilkins 2023-03-17 /pmc/articles/PMC10019177/ /pubmed/36930098 http://dx.doi.org/10.1097/MD.0000000000033279 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. |
spellingShingle | 4500 Cho, Yerim Park, Su Bee Yoon, Jin Young Kwak, Min Seob Cha, Jae Myung Neutrophil to lymphocyte ratio can predict overall survival in patients with stage II to III colorectal cancer |
title | Neutrophil to lymphocyte ratio can predict overall survival in patients with stage II to III colorectal cancer |
title_full | Neutrophil to lymphocyte ratio can predict overall survival in patients with stage II to III colorectal cancer |
title_fullStr | Neutrophil to lymphocyte ratio can predict overall survival in patients with stage II to III colorectal cancer |
title_full_unstemmed | Neutrophil to lymphocyte ratio can predict overall survival in patients with stage II to III colorectal cancer |
title_short | Neutrophil to lymphocyte ratio can predict overall survival in patients with stage II to III colorectal cancer |
title_sort | neutrophil to lymphocyte ratio can predict overall survival in patients with stage ii to iii colorectal cancer |
topic | 4500 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019177/ https://www.ncbi.nlm.nih.gov/pubmed/36930098 http://dx.doi.org/10.1097/MD.0000000000033279 |
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