A Case of a Beta-Catenin-Activated Hepatic Adenoma in a Male Patient With Familial Adenomatous Polyposis

Hepatocellular adenoma is a benign liver tumor often diagnosed incidentally in women of reproductive age who are taking oral contraceptives. In this study, we present a unique case of an 18-year-old man with known familial adenomatous polyposis who presented with sepsis in the setting of a recent to...

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Autores principales: Kusnik, Alexander, Li, Shifan, Graziano, Elliot, Katerji, Roula, Ramaraju, Gopal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019209/
https://www.ncbi.nlm.nih.gov/pubmed/36936132
http://dx.doi.org/10.14309/crj.0000000000001012
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author Kusnik, Alexander
Li, Shifan
Graziano, Elliot
Katerji, Roula
Ramaraju, Gopal
author_facet Kusnik, Alexander
Li, Shifan
Graziano, Elliot
Katerji, Roula
Ramaraju, Gopal
author_sort Kusnik, Alexander
collection PubMed
description Hepatocellular adenoma is a benign liver tumor often diagnosed incidentally in women of reproductive age who are taking oral contraceptives. In this study, we present a unique case of an 18-year-old man with known familial adenomatous polyposis who presented with sepsis in the setting of a recent total proctocolectomy and was incidentally found to have multiple large hepatic lesions. A biopsy of a liver lesion confirmed the diagnosis of a beta-catenin-activated hepatic adenoma. To the best of our knowledge, this is the first known case of beta-catenin-activated hepatic adenoma in a patient with a known familial adenomatous polyposis mutation. Beta-catenin is one of the many subtypes of hepatocellular adenomas, which carries a high risk of malignant transformation.
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spelling pubmed-100192092023-03-17 A Case of a Beta-Catenin-Activated Hepatic Adenoma in a Male Patient With Familial Adenomatous Polyposis Kusnik, Alexander Li, Shifan Graziano, Elliot Katerji, Roula Ramaraju, Gopal ACG Case Rep J Case Report Hepatocellular adenoma is a benign liver tumor often diagnosed incidentally in women of reproductive age who are taking oral contraceptives. In this study, we present a unique case of an 18-year-old man with known familial adenomatous polyposis who presented with sepsis in the setting of a recent total proctocolectomy and was incidentally found to have multiple large hepatic lesions. A biopsy of a liver lesion confirmed the diagnosis of a beta-catenin-activated hepatic adenoma. To the best of our knowledge, this is the first known case of beta-catenin-activated hepatic adenoma in a patient with a known familial adenomatous polyposis mutation. Beta-catenin is one of the many subtypes of hepatocellular adenomas, which carries a high risk of malignant transformation. Wolters Kluwer 2023-03-16 /pmc/articles/PMC10019209/ /pubmed/36936132 http://dx.doi.org/10.14309/crj.0000000000001012 Text en © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Case Report
Kusnik, Alexander
Li, Shifan
Graziano, Elliot
Katerji, Roula
Ramaraju, Gopal
A Case of a Beta-Catenin-Activated Hepatic Adenoma in a Male Patient With Familial Adenomatous Polyposis
title A Case of a Beta-Catenin-Activated Hepatic Adenoma in a Male Patient With Familial Adenomatous Polyposis
title_full A Case of a Beta-Catenin-Activated Hepatic Adenoma in a Male Patient With Familial Adenomatous Polyposis
title_fullStr A Case of a Beta-Catenin-Activated Hepatic Adenoma in a Male Patient With Familial Adenomatous Polyposis
title_full_unstemmed A Case of a Beta-Catenin-Activated Hepatic Adenoma in a Male Patient With Familial Adenomatous Polyposis
title_short A Case of a Beta-Catenin-Activated Hepatic Adenoma in a Male Patient With Familial Adenomatous Polyposis
title_sort case of a beta-catenin-activated hepatic adenoma in a male patient with familial adenomatous polyposis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019209/
https://www.ncbi.nlm.nih.gov/pubmed/36936132
http://dx.doi.org/10.14309/crj.0000000000001012
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