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Assessment of glucose and lipid metabolism in patients with polycystic ovary syndrome with and without Hashimoto’s thyroiditis

To investigate glucose and lipid metabolism in patients with polycystic ovary syndrome (PCOS) with and without Hashimoto’s thyroiditis (HT). In the present study, 103 women were included as controls and a total of 213 patients (49 patients with HT and 164 patients without HT) diagnosed with PCOS. Th...

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Autores principales: Jia, Cenlin, Zhang, Lin, Liu, Wenhua, Zhang, Xiangyan, Wu, Hongyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019210/
https://www.ncbi.nlm.nih.gov/pubmed/36930082
http://dx.doi.org/10.1097/MD.0000000000033205
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author Jia, Cenlin
Zhang, Lin
Liu, Wenhua
Zhang, Xiangyan
Wu, Hongyan
author_facet Jia, Cenlin
Zhang, Lin
Liu, Wenhua
Zhang, Xiangyan
Wu, Hongyan
author_sort Jia, Cenlin
collection PubMed
description To investigate glucose and lipid metabolism in patients with polycystic ovary syndrome (PCOS) with and without Hashimoto’s thyroiditis (HT). In the present study, 103 women were included as controls and a total of 213 patients (49 patients with HT and 164 patients without HT) diagnosed with PCOS. The oral glucose tolerance, insulin release, thyroid function, and lipid levels were measured. PCOS patients had significantly higher levels of fasting insulin (FINS), hemostasis of model assessment-insulin resistance, low-lipoprotein cholesterol, triglyceride, apolipoprotein B, apolipoprotein B/apolipoprotein A1, and homocysteine than the controls. PCOS Patients with HT + had higher FINS, 60FINS, 120FINS, and insulin resistance levels than those without Hashimoto’s thyroiditis group. HT + group had higher total cholesterol, and thyroid-stimulating hormone levels, while free triiodothyronine, and free thyroxine levels were significantly lower. PCOS can lead to disorders of glucolipid metabolism, PCOS with Hashimoto’s thyroiditis may further exacerbate disorders of glucose and lipid metabolism, and therefore thyroid function assessment in patients with PCOS needs to be emphasized.
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spelling pubmed-100192102023-03-17 Assessment of glucose and lipid metabolism in patients with polycystic ovary syndrome with and without Hashimoto’s thyroiditis Jia, Cenlin Zhang, Lin Liu, Wenhua Zhang, Xiangyan Wu, Hongyan Medicine (Baltimore) 5600 To investigate glucose and lipid metabolism in patients with polycystic ovary syndrome (PCOS) with and without Hashimoto’s thyroiditis (HT). In the present study, 103 women were included as controls and a total of 213 patients (49 patients with HT and 164 patients without HT) diagnosed with PCOS. The oral glucose tolerance, insulin release, thyroid function, and lipid levels were measured. PCOS patients had significantly higher levels of fasting insulin (FINS), hemostasis of model assessment-insulin resistance, low-lipoprotein cholesterol, triglyceride, apolipoprotein B, apolipoprotein B/apolipoprotein A1, and homocysteine than the controls. PCOS Patients with HT + had higher FINS, 60FINS, 120FINS, and insulin resistance levels than those without Hashimoto’s thyroiditis group. HT + group had higher total cholesterol, and thyroid-stimulating hormone levels, while free triiodothyronine, and free thyroxine levels were significantly lower. PCOS can lead to disorders of glucolipid metabolism, PCOS with Hashimoto’s thyroiditis may further exacerbate disorders of glucose and lipid metabolism, and therefore thyroid function assessment in patients with PCOS needs to be emphasized. Lippincott Williams & Wilkins 2023-03-17 /pmc/articles/PMC10019210/ /pubmed/36930082 http://dx.doi.org/10.1097/MD.0000000000033205 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 5600
Jia, Cenlin
Zhang, Lin
Liu, Wenhua
Zhang, Xiangyan
Wu, Hongyan
Assessment of glucose and lipid metabolism in patients with polycystic ovary syndrome with and without Hashimoto’s thyroiditis
title Assessment of glucose and lipid metabolism in patients with polycystic ovary syndrome with and without Hashimoto’s thyroiditis
title_full Assessment of glucose and lipid metabolism in patients with polycystic ovary syndrome with and without Hashimoto’s thyroiditis
title_fullStr Assessment of glucose and lipid metabolism in patients with polycystic ovary syndrome with and without Hashimoto’s thyroiditis
title_full_unstemmed Assessment of glucose and lipid metabolism in patients with polycystic ovary syndrome with and without Hashimoto’s thyroiditis
title_short Assessment of glucose and lipid metabolism in patients with polycystic ovary syndrome with and without Hashimoto’s thyroiditis
title_sort assessment of glucose and lipid metabolism in patients with polycystic ovary syndrome with and without hashimoto’s thyroiditis
topic 5600
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019210/
https://www.ncbi.nlm.nih.gov/pubmed/36930082
http://dx.doi.org/10.1097/MD.0000000000033205
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