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Assessment of glucose and lipid metabolism in patients with polycystic ovary syndrome with and without Hashimoto’s thyroiditis
To investigate glucose and lipid metabolism in patients with polycystic ovary syndrome (PCOS) with and without Hashimoto’s thyroiditis (HT). In the present study, 103 women were included as controls and a total of 213 patients (49 patients with HT and 164 patients without HT) diagnosed with PCOS. Th...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019210/ https://www.ncbi.nlm.nih.gov/pubmed/36930082 http://dx.doi.org/10.1097/MD.0000000000033205 |
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author | Jia, Cenlin Zhang, Lin Liu, Wenhua Zhang, Xiangyan Wu, Hongyan |
author_facet | Jia, Cenlin Zhang, Lin Liu, Wenhua Zhang, Xiangyan Wu, Hongyan |
author_sort | Jia, Cenlin |
collection | PubMed |
description | To investigate glucose and lipid metabolism in patients with polycystic ovary syndrome (PCOS) with and without Hashimoto’s thyroiditis (HT). In the present study, 103 women were included as controls and a total of 213 patients (49 patients with HT and 164 patients without HT) diagnosed with PCOS. The oral glucose tolerance, insulin release, thyroid function, and lipid levels were measured. PCOS patients had significantly higher levels of fasting insulin (FINS), hemostasis of model assessment-insulin resistance, low-lipoprotein cholesterol, triglyceride, apolipoprotein B, apolipoprotein B/apolipoprotein A1, and homocysteine than the controls. PCOS Patients with HT + had higher FINS, 60FINS, 120FINS, and insulin resistance levels than those without Hashimoto’s thyroiditis group. HT + group had higher total cholesterol, and thyroid-stimulating hormone levels, while free triiodothyronine, and free thyroxine levels were significantly lower. PCOS can lead to disorders of glucolipid metabolism, PCOS with Hashimoto’s thyroiditis may further exacerbate disorders of glucose and lipid metabolism, and therefore thyroid function assessment in patients with PCOS needs to be emphasized. |
format | Online Article Text |
id | pubmed-10019210 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-100192102023-03-17 Assessment of glucose and lipid metabolism in patients with polycystic ovary syndrome with and without Hashimoto’s thyroiditis Jia, Cenlin Zhang, Lin Liu, Wenhua Zhang, Xiangyan Wu, Hongyan Medicine (Baltimore) 5600 To investigate glucose and lipid metabolism in patients with polycystic ovary syndrome (PCOS) with and without Hashimoto’s thyroiditis (HT). In the present study, 103 women were included as controls and a total of 213 patients (49 patients with HT and 164 patients without HT) diagnosed with PCOS. The oral glucose tolerance, insulin release, thyroid function, and lipid levels were measured. PCOS patients had significantly higher levels of fasting insulin (FINS), hemostasis of model assessment-insulin resistance, low-lipoprotein cholesterol, triglyceride, apolipoprotein B, apolipoprotein B/apolipoprotein A1, and homocysteine than the controls. PCOS Patients with HT + had higher FINS, 60FINS, 120FINS, and insulin resistance levels than those without Hashimoto’s thyroiditis group. HT + group had higher total cholesterol, and thyroid-stimulating hormone levels, while free triiodothyronine, and free thyroxine levels were significantly lower. PCOS can lead to disorders of glucolipid metabolism, PCOS with Hashimoto’s thyroiditis may further exacerbate disorders of glucose and lipid metabolism, and therefore thyroid function assessment in patients with PCOS needs to be emphasized. Lippincott Williams & Wilkins 2023-03-17 /pmc/articles/PMC10019210/ /pubmed/36930082 http://dx.doi.org/10.1097/MD.0000000000033205 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | 5600 Jia, Cenlin Zhang, Lin Liu, Wenhua Zhang, Xiangyan Wu, Hongyan Assessment of glucose and lipid metabolism in patients with polycystic ovary syndrome with and without Hashimoto’s thyroiditis |
title | Assessment of glucose and lipid metabolism in patients with polycystic ovary syndrome with and without Hashimoto’s thyroiditis |
title_full | Assessment of glucose and lipid metabolism in patients with polycystic ovary syndrome with and without Hashimoto’s thyroiditis |
title_fullStr | Assessment of glucose and lipid metabolism in patients with polycystic ovary syndrome with and without Hashimoto’s thyroiditis |
title_full_unstemmed | Assessment of glucose and lipid metabolism in patients with polycystic ovary syndrome with and without Hashimoto’s thyroiditis |
title_short | Assessment of glucose and lipid metabolism in patients with polycystic ovary syndrome with and without Hashimoto’s thyroiditis |
title_sort | assessment of glucose and lipid metabolism in patients with polycystic ovary syndrome with and without hashimoto’s thyroiditis |
topic | 5600 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019210/ https://www.ncbi.nlm.nih.gov/pubmed/36930082 http://dx.doi.org/10.1097/MD.0000000000033205 |
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