Cargando…

Relationship between ferroptosis and mitophagy in cardiac ischemia reperfusion injury: a mini-review

Cardiovascular diseases (CVD), with high morbidity and mortality, seriously affect people’s life and social development. Clinically, reperfusion therapy is typically used to treat ischemic cardiomyopathy, such as severe coronary heart disease and acute myocardial infarction. However, reperfusion the...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Cuihua, Li, Zunjiang, Li, Botao, Liu, Wei, Zhang, Shizhong, Qiu, Kuncheng, Zhu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019339/
https://www.ncbi.nlm.nih.gov/pubmed/36935924
http://dx.doi.org/10.7717/peerj.14952
_version_ 1784908007260291072
author Liu, Cuihua
Li, Zunjiang
Li, Botao
Liu, Wei
Zhang, Shizhong
Qiu, Kuncheng
Zhu, Wei
author_facet Liu, Cuihua
Li, Zunjiang
Li, Botao
Liu, Wei
Zhang, Shizhong
Qiu, Kuncheng
Zhu, Wei
author_sort Liu, Cuihua
collection PubMed
description Cardiovascular diseases (CVD), with high morbidity and mortality, seriously affect people’s life and social development. Clinically, reperfusion therapy is typically used to treat ischemic cardiomyopathy, such as severe coronary heart disease and acute myocardial infarction. However, reperfusion therapy can lead to myocardial ischemia reperfusion injury (MIRI), which can affect the prognosis of patients. Studying the mechanisms of MIRI can help us improve the treatment of MIRI. The pathological process of MIRI involves many mechanisms such as ferroptosis and mitophagy. Ferroptosis can exacerbate MIRI, and regulation of mitophagy can alleviate MIRI. Both ferroptosis and mitophagy are closely related to ROS, but there is no clear understanding of the relationship between ferroptosis and mitophagy. In this review, we analyzed the relationship between ferroptosis and mitophagy according to the role of mTOR, NLPR3 and HIF. In addition, simultaneous regulation of mitophagy and ferroptosis may be superior to single therapy for MIRI. We summarized potential drugs that can regulate mitophagy and/or ferroptosis, hoping to provide reference for the development of drugs and methods for MIRI treatment.
format Online
Article
Text
id pubmed-10019339
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher PeerJ Inc.
record_format MEDLINE/PubMed
spelling pubmed-100193392023-03-17 Relationship between ferroptosis and mitophagy in cardiac ischemia reperfusion injury: a mini-review Liu, Cuihua Li, Zunjiang Li, Botao Liu, Wei Zhang, Shizhong Qiu, Kuncheng Zhu, Wei PeerJ Biochemistry Cardiovascular diseases (CVD), with high morbidity and mortality, seriously affect people’s life and social development. Clinically, reperfusion therapy is typically used to treat ischemic cardiomyopathy, such as severe coronary heart disease and acute myocardial infarction. However, reperfusion therapy can lead to myocardial ischemia reperfusion injury (MIRI), which can affect the prognosis of patients. Studying the mechanisms of MIRI can help us improve the treatment of MIRI. The pathological process of MIRI involves many mechanisms such as ferroptosis and mitophagy. Ferroptosis can exacerbate MIRI, and regulation of mitophagy can alleviate MIRI. Both ferroptosis and mitophagy are closely related to ROS, but there is no clear understanding of the relationship between ferroptosis and mitophagy. In this review, we analyzed the relationship between ferroptosis and mitophagy according to the role of mTOR, NLPR3 and HIF. In addition, simultaneous regulation of mitophagy and ferroptosis may be superior to single therapy for MIRI. We summarized potential drugs that can regulate mitophagy and/or ferroptosis, hoping to provide reference for the development of drugs and methods for MIRI treatment. PeerJ Inc. 2023-03-13 /pmc/articles/PMC10019339/ /pubmed/36935924 http://dx.doi.org/10.7717/peerj.14952 Text en ©2023 Liu et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Biochemistry
Liu, Cuihua
Li, Zunjiang
Li, Botao
Liu, Wei
Zhang, Shizhong
Qiu, Kuncheng
Zhu, Wei
Relationship between ferroptosis and mitophagy in cardiac ischemia reperfusion injury: a mini-review
title Relationship between ferroptosis and mitophagy in cardiac ischemia reperfusion injury: a mini-review
title_full Relationship between ferroptosis and mitophagy in cardiac ischemia reperfusion injury: a mini-review
title_fullStr Relationship between ferroptosis and mitophagy in cardiac ischemia reperfusion injury: a mini-review
title_full_unstemmed Relationship between ferroptosis and mitophagy in cardiac ischemia reperfusion injury: a mini-review
title_short Relationship between ferroptosis and mitophagy in cardiac ischemia reperfusion injury: a mini-review
title_sort relationship between ferroptosis and mitophagy in cardiac ischemia reperfusion injury: a mini-review
topic Biochemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019339/
https://www.ncbi.nlm.nih.gov/pubmed/36935924
http://dx.doi.org/10.7717/peerj.14952
work_keys_str_mv AT liucuihua relationshipbetweenferroptosisandmitophagyincardiacischemiareperfusioninjuryaminireview
AT lizunjiang relationshipbetweenferroptosisandmitophagyincardiacischemiareperfusioninjuryaminireview
AT libotao relationshipbetweenferroptosisandmitophagyincardiacischemiareperfusioninjuryaminireview
AT liuwei relationshipbetweenferroptosisandmitophagyincardiacischemiareperfusioninjuryaminireview
AT zhangshizhong relationshipbetweenferroptosisandmitophagyincardiacischemiareperfusioninjuryaminireview
AT qiukuncheng relationshipbetweenferroptosisandmitophagyincardiacischemiareperfusioninjuryaminireview
AT zhuwei relationshipbetweenferroptosisandmitophagyincardiacischemiareperfusioninjuryaminireview