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Relationship between ferroptosis and mitophagy in cardiac ischemia reperfusion injury: a mini-review
Cardiovascular diseases (CVD), with high morbidity and mortality, seriously affect people’s life and social development. Clinically, reperfusion therapy is typically used to treat ischemic cardiomyopathy, such as severe coronary heart disease and acute myocardial infarction. However, reperfusion the...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PeerJ Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019339/ https://www.ncbi.nlm.nih.gov/pubmed/36935924 http://dx.doi.org/10.7717/peerj.14952 |
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author | Liu, Cuihua Li, Zunjiang Li, Botao Liu, Wei Zhang, Shizhong Qiu, Kuncheng Zhu, Wei |
author_facet | Liu, Cuihua Li, Zunjiang Li, Botao Liu, Wei Zhang, Shizhong Qiu, Kuncheng Zhu, Wei |
author_sort | Liu, Cuihua |
collection | PubMed |
description | Cardiovascular diseases (CVD), with high morbidity and mortality, seriously affect people’s life and social development. Clinically, reperfusion therapy is typically used to treat ischemic cardiomyopathy, such as severe coronary heart disease and acute myocardial infarction. However, reperfusion therapy can lead to myocardial ischemia reperfusion injury (MIRI), which can affect the prognosis of patients. Studying the mechanisms of MIRI can help us improve the treatment of MIRI. The pathological process of MIRI involves many mechanisms such as ferroptosis and mitophagy. Ferroptosis can exacerbate MIRI, and regulation of mitophagy can alleviate MIRI. Both ferroptosis and mitophagy are closely related to ROS, but there is no clear understanding of the relationship between ferroptosis and mitophagy. In this review, we analyzed the relationship between ferroptosis and mitophagy according to the role of mTOR, NLPR3 and HIF. In addition, simultaneous regulation of mitophagy and ferroptosis may be superior to single therapy for MIRI. We summarized potential drugs that can regulate mitophagy and/or ferroptosis, hoping to provide reference for the development of drugs and methods for MIRI treatment. |
format | Online Article Text |
id | pubmed-10019339 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | PeerJ Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100193392023-03-17 Relationship between ferroptosis and mitophagy in cardiac ischemia reperfusion injury: a mini-review Liu, Cuihua Li, Zunjiang Li, Botao Liu, Wei Zhang, Shizhong Qiu, Kuncheng Zhu, Wei PeerJ Biochemistry Cardiovascular diseases (CVD), with high morbidity and mortality, seriously affect people’s life and social development. Clinically, reperfusion therapy is typically used to treat ischemic cardiomyopathy, such as severe coronary heart disease and acute myocardial infarction. However, reperfusion therapy can lead to myocardial ischemia reperfusion injury (MIRI), which can affect the prognosis of patients. Studying the mechanisms of MIRI can help us improve the treatment of MIRI. The pathological process of MIRI involves many mechanisms such as ferroptosis and mitophagy. Ferroptosis can exacerbate MIRI, and regulation of mitophagy can alleviate MIRI. Both ferroptosis and mitophagy are closely related to ROS, but there is no clear understanding of the relationship between ferroptosis and mitophagy. In this review, we analyzed the relationship between ferroptosis and mitophagy according to the role of mTOR, NLPR3 and HIF. In addition, simultaneous regulation of mitophagy and ferroptosis may be superior to single therapy for MIRI. We summarized potential drugs that can regulate mitophagy and/or ferroptosis, hoping to provide reference for the development of drugs and methods for MIRI treatment. PeerJ Inc. 2023-03-13 /pmc/articles/PMC10019339/ /pubmed/36935924 http://dx.doi.org/10.7717/peerj.14952 Text en ©2023 Liu et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited. |
spellingShingle | Biochemistry Liu, Cuihua Li, Zunjiang Li, Botao Liu, Wei Zhang, Shizhong Qiu, Kuncheng Zhu, Wei Relationship between ferroptosis and mitophagy in cardiac ischemia reperfusion injury: a mini-review |
title | Relationship between ferroptosis and mitophagy in cardiac ischemia reperfusion injury: a mini-review |
title_full | Relationship between ferroptosis and mitophagy in cardiac ischemia reperfusion injury: a mini-review |
title_fullStr | Relationship between ferroptosis and mitophagy in cardiac ischemia reperfusion injury: a mini-review |
title_full_unstemmed | Relationship between ferroptosis and mitophagy in cardiac ischemia reperfusion injury: a mini-review |
title_short | Relationship between ferroptosis and mitophagy in cardiac ischemia reperfusion injury: a mini-review |
title_sort | relationship between ferroptosis and mitophagy in cardiac ischemia reperfusion injury: a mini-review |
topic | Biochemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019339/ https://www.ncbi.nlm.nih.gov/pubmed/36935924 http://dx.doi.org/10.7717/peerj.14952 |
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