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Endosomal escape of RNA therapeutics: How do we solve this rate-limiting problem?
With over 15 FDA approved drugs on the market and numerous ongoing clinical trials, RNA therapeutics, such as small interfering RNAs (siRNAs) and antisense oligonucleotides (ASOs), have shown great potential to treat human disease. Their mechanism of action is based entirely on the sequence of valid...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory Press
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019367/ https://www.ncbi.nlm.nih.gov/pubmed/36669888 http://dx.doi.org/10.1261/rna.079507.122 |