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Neurostimulation for Traumatic Brain Injury: Emerging Innovation

Traumatic brain injury (TBI) is a significant source of brain deficit and death among neurosurgical patients, with limited prospects for functional recovery in the cases of moderate-to-severe injury. Until now, the relevant body of literature on TBI intervention has focused on first-line, invasive t...

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Autores principales: Diaz, Michael Joseph, Root, Kevin Thomas, Beneke, Alice, Penev, Yordan, Lucke-Wold, Brandon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019379/
https://www.ncbi.nlm.nih.gov/pubmed/36938307
http://dx.doi.org/10.21926/obm.neurobiol.2301161
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author Diaz, Michael Joseph
Root, Kevin Thomas
Beneke, Alice
Penev, Yordan
Lucke-Wold, Brandon
author_facet Diaz, Michael Joseph
Root, Kevin Thomas
Beneke, Alice
Penev, Yordan
Lucke-Wold, Brandon
author_sort Diaz, Michael Joseph
collection PubMed
description Traumatic brain injury (TBI) is a significant source of brain deficit and death among neurosurgical patients, with limited prospects for functional recovery in the cases of moderate-to-severe injury. Until now, the relevant body of literature on TBI intervention has focused on first-line, invasive treatment options (namely craniectomy and hematoma evacuation) with underwhelming focus on non-invasive therapies following surgical stabilization. Recent advances in our understanding of the impaired brain have encouraged deeper investigation of neurostimulation strategies, owed largely to its demonstrated livening of damaged neural circuitry and capacity to stabilize erratic network activity. The objective of the present study is to provide a scoping review of new knowledge in neurostimulation published in the PubMed, Scopus, and Google Scholar databases from inception to November 2022. We critically assess and appraise the available data on primary neurostimulation delivery techniques, with marked emphasis on restorative opportunities for accessory neurostimulation in the interdisciplinary care of moderate-to-severe TBI (msTBI) patients. These data identify two primary future directions: 1) to relate obtained gain-of-function outcomes to hemodynamic and histological changes and 2) to develop a clearer understanding of neurostimulation efficacy, when combined with pharmacologic interventions or other modulatory techniques, for complex brain insult.
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spelling pubmed-100193792023-03-16 Neurostimulation for Traumatic Brain Injury: Emerging Innovation Diaz, Michael Joseph Root, Kevin Thomas Beneke, Alice Penev, Yordan Lucke-Wold, Brandon OBM Neurobiol Article Traumatic brain injury (TBI) is a significant source of brain deficit and death among neurosurgical patients, with limited prospects for functional recovery in the cases of moderate-to-severe injury. Until now, the relevant body of literature on TBI intervention has focused on first-line, invasive treatment options (namely craniectomy and hematoma evacuation) with underwhelming focus on non-invasive therapies following surgical stabilization. Recent advances in our understanding of the impaired brain have encouraged deeper investigation of neurostimulation strategies, owed largely to its demonstrated livening of damaged neural circuitry and capacity to stabilize erratic network activity. The objective of the present study is to provide a scoping review of new knowledge in neurostimulation published in the PubMed, Scopus, and Google Scholar databases from inception to November 2022. We critically assess and appraise the available data on primary neurostimulation delivery techniques, with marked emphasis on restorative opportunities for accessory neurostimulation in the interdisciplinary care of moderate-to-severe TBI (msTBI) patients. These data identify two primary future directions: 1) to relate obtained gain-of-function outcomes to hemodynamic and histological changes and 2) to develop a clearer understanding of neurostimulation efficacy, when combined with pharmacologic interventions or other modulatory techniques, for complex brain insult. 2023 2023-03-06 /pmc/articles/PMC10019379/ /pubmed/36938307 http://dx.doi.org/10.21926/obm.neurobiol.2301161 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the conditions of the Creative Commons by Attribution License, which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is correctly cited.
spellingShingle Article
Diaz, Michael Joseph
Root, Kevin Thomas
Beneke, Alice
Penev, Yordan
Lucke-Wold, Brandon
Neurostimulation for Traumatic Brain Injury: Emerging Innovation
title Neurostimulation for Traumatic Brain Injury: Emerging Innovation
title_full Neurostimulation for Traumatic Brain Injury: Emerging Innovation
title_fullStr Neurostimulation for Traumatic Brain Injury: Emerging Innovation
title_full_unstemmed Neurostimulation for Traumatic Brain Injury: Emerging Innovation
title_short Neurostimulation for Traumatic Brain Injury: Emerging Innovation
title_sort neurostimulation for traumatic brain injury: emerging innovation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019379/
https://www.ncbi.nlm.nih.gov/pubmed/36938307
http://dx.doi.org/10.21926/obm.neurobiol.2301161
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