Cargando…
Neurostimulation for Traumatic Brain Injury: Emerging Innovation
Traumatic brain injury (TBI) is a significant source of brain deficit and death among neurosurgical patients, with limited prospects for functional recovery in the cases of moderate-to-severe injury. Until now, the relevant body of literature on TBI intervention has focused on first-line, invasive t...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019379/ https://www.ncbi.nlm.nih.gov/pubmed/36938307 http://dx.doi.org/10.21926/obm.neurobiol.2301161 |
_version_ | 1784908015153971200 |
---|---|
author | Diaz, Michael Joseph Root, Kevin Thomas Beneke, Alice Penev, Yordan Lucke-Wold, Brandon |
author_facet | Diaz, Michael Joseph Root, Kevin Thomas Beneke, Alice Penev, Yordan Lucke-Wold, Brandon |
author_sort | Diaz, Michael Joseph |
collection | PubMed |
description | Traumatic brain injury (TBI) is a significant source of brain deficit and death among neurosurgical patients, with limited prospects for functional recovery in the cases of moderate-to-severe injury. Until now, the relevant body of literature on TBI intervention has focused on first-line, invasive treatment options (namely craniectomy and hematoma evacuation) with underwhelming focus on non-invasive therapies following surgical stabilization. Recent advances in our understanding of the impaired brain have encouraged deeper investigation of neurostimulation strategies, owed largely to its demonstrated livening of damaged neural circuitry and capacity to stabilize erratic network activity. The objective of the present study is to provide a scoping review of new knowledge in neurostimulation published in the PubMed, Scopus, and Google Scholar databases from inception to November 2022. We critically assess and appraise the available data on primary neurostimulation delivery techniques, with marked emphasis on restorative opportunities for accessory neurostimulation in the interdisciplinary care of moderate-to-severe TBI (msTBI) patients. These data identify two primary future directions: 1) to relate obtained gain-of-function outcomes to hemodynamic and histological changes and 2) to develop a clearer understanding of neurostimulation efficacy, when combined with pharmacologic interventions or other modulatory techniques, for complex brain insult. |
format | Online Article Text |
id | pubmed-10019379 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
record_format | MEDLINE/PubMed |
spelling | pubmed-100193792023-03-16 Neurostimulation for Traumatic Brain Injury: Emerging Innovation Diaz, Michael Joseph Root, Kevin Thomas Beneke, Alice Penev, Yordan Lucke-Wold, Brandon OBM Neurobiol Article Traumatic brain injury (TBI) is a significant source of brain deficit and death among neurosurgical patients, with limited prospects for functional recovery in the cases of moderate-to-severe injury. Until now, the relevant body of literature on TBI intervention has focused on first-line, invasive treatment options (namely craniectomy and hematoma evacuation) with underwhelming focus on non-invasive therapies following surgical stabilization. Recent advances in our understanding of the impaired brain have encouraged deeper investigation of neurostimulation strategies, owed largely to its demonstrated livening of damaged neural circuitry and capacity to stabilize erratic network activity. The objective of the present study is to provide a scoping review of new knowledge in neurostimulation published in the PubMed, Scopus, and Google Scholar databases from inception to November 2022. We critically assess and appraise the available data on primary neurostimulation delivery techniques, with marked emphasis on restorative opportunities for accessory neurostimulation in the interdisciplinary care of moderate-to-severe TBI (msTBI) patients. These data identify two primary future directions: 1) to relate obtained gain-of-function outcomes to hemodynamic and histological changes and 2) to develop a clearer understanding of neurostimulation efficacy, when combined with pharmacologic interventions or other modulatory techniques, for complex brain insult. 2023 2023-03-06 /pmc/articles/PMC10019379/ /pubmed/36938307 http://dx.doi.org/10.21926/obm.neurobiol.2301161 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the conditions of the Creative Commons by Attribution License, which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is correctly cited. |
spellingShingle | Article Diaz, Michael Joseph Root, Kevin Thomas Beneke, Alice Penev, Yordan Lucke-Wold, Brandon Neurostimulation for Traumatic Brain Injury: Emerging Innovation |
title | Neurostimulation for Traumatic Brain Injury: Emerging Innovation |
title_full | Neurostimulation for Traumatic Brain Injury: Emerging Innovation |
title_fullStr | Neurostimulation for Traumatic Brain Injury: Emerging Innovation |
title_full_unstemmed | Neurostimulation for Traumatic Brain Injury: Emerging Innovation |
title_short | Neurostimulation for Traumatic Brain Injury: Emerging Innovation |
title_sort | neurostimulation for traumatic brain injury: emerging innovation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019379/ https://www.ncbi.nlm.nih.gov/pubmed/36938307 http://dx.doi.org/10.21926/obm.neurobiol.2301161 |
work_keys_str_mv | AT diazmichaeljoseph neurostimulationfortraumaticbraininjuryemerginginnovation AT rootkevinthomas neurostimulationfortraumaticbraininjuryemerginginnovation AT benekealice neurostimulationfortraumaticbraininjuryemerginginnovation AT penevyordan neurostimulationfortraumaticbraininjuryemerginginnovation AT luckewoldbrandon neurostimulationfortraumaticbraininjuryemerginginnovation |