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Blood flow pattern in eye before development of type 3 macular neovascularization

PURPOSE: To determine the blood flow pattern of eyes before the development of type 3 macular neovascularization (MNV) by optical coherence tomography angiography (OCTA). STUDY DESIGN: Retrospective study. SUBJECTS: Ten eyes of 10 patients (4 men and 6 women, mean age 80.4 years) diagnosed with unil...

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Autores principales: Yamaguchi, Saya, Maruko, Ichiro, Maruko, Ruka, Hasegawa, Taiji, Iida, Tomohiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019608/
https://www.ncbi.nlm.nih.gov/pubmed/36928265
http://dx.doi.org/10.1371/journal.pone.0283202
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author Yamaguchi, Saya
Maruko, Ichiro
Maruko, Ruka
Hasegawa, Taiji
Iida, Tomohiro
author_facet Yamaguchi, Saya
Maruko, Ichiro
Maruko, Ruka
Hasegawa, Taiji
Iida, Tomohiro
author_sort Yamaguchi, Saya
collection PubMed
description PURPOSE: To determine the blood flow pattern of eyes before the development of type 3 macular neovascularization (MNV) by optical coherence tomography angiography (OCTA). STUDY DESIGN: Retrospective study. SUBJECTS: Ten eyes of 10 patients (4 men and 6 women, mean age 80.4 years) diagnosed with unilateral Type 3 MNV who developed type 3 MNV in the fellow normal eye during the follow-up period were studied. METHODS: The time of onset of type 3 MNV was defined as the time when retinal exudation was detected by OCT. The blood flow of a 3 x 3 mm or 6 x 6 mm area in the deep capillary plexus (DCP) and the outer retina (OR) including the central fovea were assessed at the onset and at 6 months prior to the onset of the type 3 MNV. RESULTS: All MNVs that developed in the fellow eye were type 3 MNVs. Abnormal blood flow signals in the MNVs were detected in the DCP and/or the OR by OCTA at the onset in all cases. Eight of the 10 eyes had OCTA recordings prior to the development of the MNV: 3 eyes had non-exudative MNVs only in the DCP and 5 eyes had non-exudative MNVs in the DCP and OR. The exudation appeared on the average 3.5 months after the non-exudative MNV was observed in the fellow eyes. CONCLUSIONS: A non-exudative MNV in the fellow eyes can already be observed by OCTA in eyes before the onset of the exudation. Knowing this will help clinicians not only how to treat these eyes appropriately but will also help in determining the origin of the MNV.
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spelling pubmed-100196082023-03-17 Blood flow pattern in eye before development of type 3 macular neovascularization Yamaguchi, Saya Maruko, Ichiro Maruko, Ruka Hasegawa, Taiji Iida, Tomohiro PLoS One Research Article PURPOSE: To determine the blood flow pattern of eyes before the development of type 3 macular neovascularization (MNV) by optical coherence tomography angiography (OCTA). STUDY DESIGN: Retrospective study. SUBJECTS: Ten eyes of 10 patients (4 men and 6 women, mean age 80.4 years) diagnosed with unilateral Type 3 MNV who developed type 3 MNV in the fellow normal eye during the follow-up period were studied. METHODS: The time of onset of type 3 MNV was defined as the time when retinal exudation was detected by OCT. The blood flow of a 3 x 3 mm or 6 x 6 mm area in the deep capillary plexus (DCP) and the outer retina (OR) including the central fovea were assessed at the onset and at 6 months prior to the onset of the type 3 MNV. RESULTS: All MNVs that developed in the fellow eye were type 3 MNVs. Abnormal blood flow signals in the MNVs were detected in the DCP and/or the OR by OCTA at the onset in all cases. Eight of the 10 eyes had OCTA recordings prior to the development of the MNV: 3 eyes had non-exudative MNVs only in the DCP and 5 eyes had non-exudative MNVs in the DCP and OR. The exudation appeared on the average 3.5 months after the non-exudative MNV was observed in the fellow eyes. CONCLUSIONS: A non-exudative MNV in the fellow eyes can already be observed by OCTA in eyes before the onset of the exudation. Knowing this will help clinicians not only how to treat these eyes appropriately but will also help in determining the origin of the MNV. Public Library of Science 2023-03-16 /pmc/articles/PMC10019608/ /pubmed/36928265 http://dx.doi.org/10.1371/journal.pone.0283202 Text en © 2023 Yamaguchi et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Yamaguchi, Saya
Maruko, Ichiro
Maruko, Ruka
Hasegawa, Taiji
Iida, Tomohiro
Blood flow pattern in eye before development of type 3 macular neovascularization
title Blood flow pattern in eye before development of type 3 macular neovascularization
title_full Blood flow pattern in eye before development of type 3 macular neovascularization
title_fullStr Blood flow pattern in eye before development of type 3 macular neovascularization
title_full_unstemmed Blood flow pattern in eye before development of type 3 macular neovascularization
title_short Blood flow pattern in eye before development of type 3 macular neovascularization
title_sort blood flow pattern in eye before development of type 3 macular neovascularization
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019608/
https://www.ncbi.nlm.nih.gov/pubmed/36928265
http://dx.doi.org/10.1371/journal.pone.0283202
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