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Targeting NAD+ regeneration enhances antibiotic susceptibility of Streptococcus pneumoniae during invasive disease

Anaerobic bacteria are responsible for half of all pulmonary infections. One such pathogen is Streptococcus pneumoniae (Spn), a leading cause of community-acquired pneumonia, bacteremia/sepsis, and meningitis. Using a panel of isogenic mutants deficient in lactate, acetyl-CoA, and ethanol fermentati...

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Detalles Bibliográficos
Autores principales:	Im, Hansol, Pearson, Madison L., Martinez, Eriel, Cichos, Kyle H., Song, Xiuhong, Kruckow, Katherine L., Andrews, Rachel M., Ghanem, Elie S., Orihuela, Carlos J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019625/ https://www.ncbi.nlm.nih.gov/pubmed/36928033 http://dx.doi.org/10.1371/journal.pbio.3002020

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