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Autophagic flux is impaired in the brain tissue of Tay-Sachs disease mouse model

Tay-Sachs disease is a lethal lysosomal storage disorder caused by mutations in the HexA gene encoding the α subunit of the lysosomal β-hexosaminidase enzyme (HEXA). Abnormal GM2 ganglioside accumulation causes progressive deterioration in the central nervous system in Tay-Sachs patients. Hexa-/- mo...

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Detalles Bibliográficos
Autores principales:	Sengul, Tugce, Can, Melike, Ateş, Nurselin, Seyrantepe, Volkan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019743/ https://www.ncbi.nlm.nih.gov/pubmed/36928510 http://dx.doi.org/10.1371/journal.pone.0280650

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