CAR-iNKT cells targeting clonal TCRVβ chains as a precise strategy to treat T cell lymphoma

INTRODUCTION: Most T cell receptor (TCR)Vβ chain-expressing T cell lymphomas (TCL) including those caused by Human T cell leukaemia virus type-1 (HTLV-1) have poor prognosis. We hypothesised that chimeric antigen receptor (CAR)-mediated targeting of the clonal, lymphoma-associated TCRβ chains would...

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Detalles Bibliográficos
Autores principales: Rowan, Aileen G., Ponnusamy, Kanagaraju, Ren, Hongwei, Taylor, Graham P., Cook, Lucy B. M., Karadimitris, Anastasios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019783/
https://www.ncbi.nlm.nih.gov/pubmed/36936927
http://dx.doi.org/10.3389/fimmu.2023.1118681

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