Cargando…

METTL3 regulates breast cancer-associated alternative splicing switches

Alternative splicing (AS) enables differential inclusion of exons from a given transcript, thereby contributing to the transcriptome and proteome diversity. Aberrant AS patterns play major roles in the development of different pathologies, including breast cancer. N(6)-methyladenosine (m(6)A), the m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Achour, Cyrinne, Bhattarai, Devi Prasad, Groza, Paula, Román, Ángel-Carlos, Aguilo, Francesca
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020087/ https://www.ncbi.nlm.nih.gov/pubmed/36725888 http://dx.doi.org/10.1038/s41388-023-02602-z

Ejemplares similares

ZFP207 sustains pluripotency by coordinating OCT4 stability, alternative splicing and RNA export
por: Malla, Sandhya, et al.
Publicado: (2022)

Dissecting the effects of METTL3 on alternative splicing in prostate cancer
por: Wang, Lin, et al.
Publicado: (2023)

Alternative splicing of METTL3 explains apparently METTL3-independent m(6)A modifications in mRNA
por: Poh, Hui Xian, et al.
Publicado: (2022)

An Alternatively Spliced Variant of METTL3 Mediates Tumor Suppression in Hepatocellular Carcinoma
por: Xu, Rui-Yao, et al.
Publicado: (2022)

Mettl3 Regulates Osteogenic Differentiation and Alternative Splicing of Vegfa in Bone Marrow Mesenchymal Stem Cells
por: Tian, Cheng, et al.
Publicado: (2019)

Regulatory roles of RNA modifications in breast cancer
por: Kumari, Kanchan, et al.
Publicado: (2021)

METTL3 regulates alternative splicing of MyD88 upon the lipopolysaccharide‐induced inflammatory response in human dental pulp cells
por: Feng, Zhihui, et al.
Publicado: (2018)

Molecular basis for human mitochondrial tRNA m(3)C modification by alternatively spliced METTL8
por: Huang, Meng-Han, et al.
Publicado: (2022)

The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer
por: Rengasamy, Madhumitha, et al.
Publicado: (2017)

An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer
por: Li, Ji, et al.
Publicado: (2018)

Alternative splicing regulation at tandem 3′ splice sites
por: Akerman, Martin, et al.
Publicado: (2006)

Cell-type specific regulator RBPMS switches alternative splicing via higher-order oligomerization and heterotypic interactions with other splicing regulators
por: Yang, Yi, et al.
Publicado: (2023)

A cleaved METTL3 potentiates the METTL3–WTAP interaction and breast cancer progression
por: Yan, Chaojun, et al.
Publicado: (2023)

Ion channel chameleons: Switching ion selectivity by alternative splicing
por: Hsu, Allen L., et al.
Publicado: (2023)

Alternative Splicing as a Regulator of Early Plant Development
por: Szakonyi, Dóra, et al.
Publicado: (2018)

The Distinct Function and Localization of METTL3/METTL14 and METTL16 Enzymes in Cardiomyocytes
por: Arcidiacono, Orazio Angelo, et al.
Publicado: (2020)

Mechano-Regulation of Alternative Splicing
por: Liu, Huan, et al.
Publicado: (2013)

Cohesin regulates alternative splicing
por: Singh, Amit K., et al.
Publicado: (2023)

Evolution of Alternative Splicing Regulation: Changes in Predicted Exonic Splicing Regulators Are Not Associated with Changes in Alternative Splicing Levels in Primates
por: Irimia, Manuel, et al.
Publicado: (2009)

Oncogenic Alternative Splicing Switches: Role in Cancer Progression and Prospects for Therapy
por: Bonomi, Serena, et al.
Publicado: (2013)

Tuning of Alternative Splicing - Switch From Proto-Oncogene to Tumor Suppressor
por: Shchelkunova, Aleksandra, et al.
Publicado: (2012)

Analysis of METTL3 and METTL14 in hepatocellular carcinoma
por: Liu, Xiangxiang, et al.
Publicado: (2020)

Modulation of MKNK2 alternative splicing by splice-switching oligonucleotides as a novel approach for glioblastoma treatment
por: Mogilevsky, Maxim, et al.
Publicado: (2018)

Aberrant alternative splicing in breast cancer
por: Yang, Quan, et al.
Publicado: (2019)

Opposing regulation of the Nα-trimethylase METTL11A by its family members METTL11B and METTL13
por: Parker, Haley V., et al.
Publicado: (2023)

METTL3 regulates WTAP protein homeostasis
por: Sorci, Melissa, et al.
Publicado: (2018)

Regulation of Methylase METTL3 on Fat Deposition
por: Luo, Gang, et al.
Publicado: (2021)

Protein Modularity of Alternatively Spliced Exons Is Associated with Tissue-Specific Regulation of Alternative Splicing
por: Xing, Yi, et al.
Publicado: (2005)

The RNA Methyltransferase Complex of WTAP, METTL3, and METTL14 Regulates Mitotic Clonal Expansion in Adipogenesis
por: Kobayashi, Masatoshi, et al.
Publicado: (2018)

A cryptic pocket in METTL3-METTL14 regulates m(6)A conversion and sensing
por: Qi, Shan, et al.
Publicado: (2023)

The Non-Coding RNA Journal Club: Highlights on Recent Papers—5
por: Achour, Cyrinne, et al.
Publicado: (2017)

SRRM2 organizes splicing condensates to regulate alternative splicing
por: Xu, Shaohai, et al.
Publicado: (2022)

Switched alternative splicing events as attractive features in lung squamous cell carcinoma
por: He, Boxue, et al.
Publicado: (2022)

Regulated functional alternative splicing in Drosophila
por: Venables, Julian P., et al.
Publicado: (2012)

Depolarization-Mediated Regulation of Alternative Splicing
por: Sharma, Alok, et al.
Publicado: (2011)

Editorial: Alternative Splicing Regulation in Plants
por: Petrillo, Ezequiel, et al.
Publicado: (2020)

Regulation of alternative splicing and polyadenylation in neurons
por: Lee, Seungjae, et al.
Publicado: (2023)

DDX5/METTL3-METTL14/YTHDF2 Axis Regulates Replication of Influenza A Virus
por: Zhao, Lingcai, et al.
Publicado: (2022)

Alternative splicing and the progesterone receptor in breast cancer
por: Cork, David MW, et al.
Publicado: (2008)

Contribution of alternative splicing to breast cancer metastasis
por: Meng, Xiangbing, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_liu5hu036k9gfpfth462ue0mfn