Loss of Splicing Factor SRSF3 Impairs Lipophagy Through Ubiquitination and Degradation of Syntaxin17 in Hepatocytes

Lipid accumulation in hepatocytes is the distinctive characteristic of nonalcoholic fatty liver disease. Serine/arginine-rich splicing factor 3 (SRSF3) is highly expressed in the liver and expression decreases in high-fat conditions. However, the role of SRSF3 in hepatic lipid metabolism needs to be...

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Detalles Bibliográficos
Autores principales: Li, Yun, Wang, Tao, Liao, Qiumin, Luo, Xiaoting, Wang, Xing, Zeng, Shu, You, Mengyue, Chen, Yaxi, Ruan, Xiong Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020108/
https://www.ncbi.nlm.nih.gov/pubmed/36764525
http://dx.doi.org/10.1016/j.jlr.2023.100342

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