HIF1α-BNIP3-mediated mitophagy protects against renal fibrosis by decreasing ROS and inhibiting activation of the NLRP3 inflammasome

Chronic kidney disease affects approximately 14.3% of people worldwide. Tubulointerstitial fibrosis is the final stage of almost all progressive CKD. To date, the pathogenesis of renal fibrosis remains unclear, and there is a lack of effective treatments, leading to renal replacement therapy. Mitoph...

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Detalles Bibliográficos
Autores principales: Li, Jialin, Lin, Qisheng, Shao, Xinghua, Li, Shu, Zhu, Xuying, Wu, Jingkui, Mou, Shan, Gu, Leyi, Wang, Qin, Zhang, Minfang, Zhang, Kaiqi, Lu, Jiayue, Ni, Zhaohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020151/
https://www.ncbi.nlm.nih.gov/pubmed/36928344
http://dx.doi.org/10.1038/s41419-023-05587-5

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