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Combinatorial effects on gene expression at the Lbx1/Fgf8 locus resolve split-hand/foot malformation type 3

Split-Hand/Foot Malformation type 3 (SHFM3) is a congenital limb malformation associated with tandem duplications at the LBX1/FGF8 locus. Yet, the disease patho-mechanism remains unsolved. Here we investigate the functional consequences of SHFM3-associated rearrangements on chromatin conformation an...

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Detalles Bibliográficos
Autores principales:	Cova, Giulia, Glaser, Juliane, Schöpflin, Robert, Prada-Medina, Cesar Augusto, Ali, Salaheddine, Franke, Martin, Falcone, Rita, Federer, Miriam, Ponzi, Emanuela, Ficarella, Romina, Novara, Francesca, Wittler, Lars, Timmermann, Bernd, Gentile, Mattia, Zuffardi, Orsetta, Spielmann, Malte, Mundlos, Stefan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020157/ https://www.ncbi.nlm.nih.gov/pubmed/36928426 http://dx.doi.org/10.1038/s41467-023-37057-z

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