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Top 10 research priorities in colorectal cancer: results from the Colorectal Cancer Priority-Setting Partnership

BACKGROUND: Colorectal cancer (CRC) is the third most frequent cause of cancer death in the word. Which aspects of research into CRC should be accorded the highest priority remains unclear, because relevant stakeholders, such as patients, nurses, and physicians, played hardly any part in the develop...

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Autores principales: Klotz, Rosa, Holze, Magdalena, Dörr-Harim, Colette, Grohmann, Erich, Nied, Barbara, Lebert, Burkhard, Weg-Remers, Susanne, Lutz, Claudia, Meißler, Karin, Schloss, Patrick, Ullrich, Charlotte, Frankenhauser, Susanne, Lutter, Heidi, Bühler, Diedrich, Ahmed, Azaz, Gronlund, Toto, Mihaljevic, André L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020251/
https://www.ncbi.nlm.nih.gov/pubmed/35579718
http://dx.doi.org/10.1007/s00432-022-04042-w
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author Klotz, Rosa
Holze, Magdalena
Dörr-Harim, Colette
Grohmann, Erich
Nied, Barbara
Lebert, Burkhard
Weg-Remers, Susanne
Lutz, Claudia
Meißler, Karin
Schloss, Patrick
Ullrich, Charlotte
Frankenhauser, Susanne
Lutter, Heidi
Bühler, Diedrich
Ahmed, Azaz
Gronlund, Toto
Mihaljevic, André L.
author_facet Klotz, Rosa
Holze, Magdalena
Dörr-Harim, Colette
Grohmann, Erich
Nied, Barbara
Lebert, Burkhard
Weg-Remers, Susanne
Lutz, Claudia
Meißler, Karin
Schloss, Patrick
Ullrich, Charlotte
Frankenhauser, Susanne
Lutter, Heidi
Bühler, Diedrich
Ahmed, Azaz
Gronlund, Toto
Mihaljevic, André L.
author_sort Klotz, Rosa
collection PubMed
description BACKGROUND: Colorectal cancer (CRC) is the third most frequent cause of cancer death in the word. Which aspects of research into CRC should be accorded the highest priority remains unclear, because relevant stakeholders, such as patients, nurses, and physicians, played hardly any part in the development of research projects. The goal in forming the CRC Priority-Setting Partnership (PSP) was to bring all relevant stakeholders together to identify and prioritize unresolved research questions regarding the diagnosis, treatment, and follow-up of CRC. METHODS: The CRC PSP worked in cooperation with the British James Lind Alliance. An initial nationwide survey was conducted, and evidence uncertainties were collected, categorized, summarized, and compared with available evidence from the literature. The as-yet unresolved questions were (provisionally) ranked in a second national wide survey, and at a concluding consensus workshop all stakeholders came together to finalize the rankings in a nominal group process and compile a top 10 list. RESULTS: In the first survey (34% patients, 51% healthcare professionals, 15% unknown), 1102 submissions were made. After exclusion of duplicates and previously resolved questions, 66 topics were then ranked in the second survey (56% patients, 39% healthcare professionals, 5% unknown). This interim ranking process revealed distinct differences between relatives and healthcare professionals. The final top 10 list compiled at the consensus workshop covers a wide area of research topics. CONCLUSION: All relevant stakeholders in the CRC PSP worked together to identify and prioritize the top 10 evidence uncertainties. The results give researchers and funding bodies the opportunity to address the most patient-relevant research projects. It is the first detailed description of a PSP in Germany, and the first PSP on CRC care worldwide. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00432-022-04042-w.
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spelling pubmed-100202512023-03-18 Top 10 research priorities in colorectal cancer: results from the Colorectal Cancer Priority-Setting Partnership Klotz, Rosa Holze, Magdalena Dörr-Harim, Colette Grohmann, Erich Nied, Barbara Lebert, Burkhard Weg-Remers, Susanne Lutz, Claudia Meißler, Karin Schloss, Patrick Ullrich, Charlotte Frankenhauser, Susanne Lutter, Heidi Bühler, Diedrich Ahmed, Azaz Gronlund, Toto Mihaljevic, André L. J Cancer Res Clin Oncol Original Article – Clinical Oncology BACKGROUND: Colorectal cancer (CRC) is the third most frequent cause of cancer death in the word. Which aspects of research into CRC should be accorded the highest priority remains unclear, because relevant stakeholders, such as patients, nurses, and physicians, played hardly any part in the development of research projects. The goal in forming the CRC Priority-Setting Partnership (PSP) was to bring all relevant stakeholders together to identify and prioritize unresolved research questions regarding the diagnosis, treatment, and follow-up of CRC. METHODS: The CRC PSP worked in cooperation with the British James Lind Alliance. An initial nationwide survey was conducted, and evidence uncertainties were collected, categorized, summarized, and compared with available evidence from the literature. The as-yet unresolved questions were (provisionally) ranked in a second national wide survey, and at a concluding consensus workshop all stakeholders came together to finalize the rankings in a nominal group process and compile a top 10 list. RESULTS: In the first survey (34% patients, 51% healthcare professionals, 15% unknown), 1102 submissions were made. After exclusion of duplicates and previously resolved questions, 66 topics were then ranked in the second survey (56% patients, 39% healthcare professionals, 5% unknown). This interim ranking process revealed distinct differences between relatives and healthcare professionals. The final top 10 list compiled at the consensus workshop covers a wide area of research topics. CONCLUSION: All relevant stakeholders in the CRC PSP worked together to identify and prioritize the top 10 evidence uncertainties. The results give researchers and funding bodies the opportunity to address the most patient-relevant research projects. It is the first detailed description of a PSP in Germany, and the first PSP on CRC care worldwide. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00432-022-04042-w. Springer Berlin Heidelberg 2022-05-17 2023 /pmc/articles/PMC10020251/ /pubmed/35579718 http://dx.doi.org/10.1007/s00432-022-04042-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article – Clinical Oncology
Klotz, Rosa
Holze, Magdalena
Dörr-Harim, Colette
Grohmann, Erich
Nied, Barbara
Lebert, Burkhard
Weg-Remers, Susanne
Lutz, Claudia
Meißler, Karin
Schloss, Patrick
Ullrich, Charlotte
Frankenhauser, Susanne
Lutter, Heidi
Bühler, Diedrich
Ahmed, Azaz
Gronlund, Toto
Mihaljevic, André L.
Top 10 research priorities in colorectal cancer: results from the Colorectal Cancer Priority-Setting Partnership
title Top 10 research priorities in colorectal cancer: results from the Colorectal Cancer Priority-Setting Partnership
title_full Top 10 research priorities in colorectal cancer: results from the Colorectal Cancer Priority-Setting Partnership
title_fullStr Top 10 research priorities in colorectal cancer: results from the Colorectal Cancer Priority-Setting Partnership
title_full_unstemmed Top 10 research priorities in colorectal cancer: results from the Colorectal Cancer Priority-Setting Partnership
title_short Top 10 research priorities in colorectal cancer: results from the Colorectal Cancer Priority-Setting Partnership
title_sort top 10 research priorities in colorectal cancer: results from the colorectal cancer priority-setting partnership
topic Original Article – Clinical Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020251/
https://www.ncbi.nlm.nih.gov/pubmed/35579718
http://dx.doi.org/10.1007/s00432-022-04042-w
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