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Five-year clinical outcomes of a 2.25 mm sirolimus-eluting stent in Japanese patients with very small coronary artery disease: final results of the CENTURY JSV study

The aim of this study is to evaluate the long-term safety and efficacy of the 2.25 mm bioresorbable-polymer sirolimus-eluting Ultimaster stent in a Japanese patient population. Treatment of coronary artery disease in very small vessels is associated with an increased risk for cardiac events. The CEN...

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Autores principales: Shishido, Koki, Ando, Kenji, Ito, Yoshiaki, Takamisawa, Itaru, Yajima, Junji, Kimura, Takeshi, Kadota, Kazushige, Saito, Shigeru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020298/
https://www.ncbi.nlm.nih.gov/pubmed/36050624
http://dx.doi.org/10.1007/s12928-022-00890-y
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author Shishido, Koki
Ando, Kenji
Ito, Yoshiaki
Takamisawa, Itaru
Yajima, Junji
Kimura, Takeshi
Kadota, Kazushige
Saito, Shigeru
author_facet Shishido, Koki
Ando, Kenji
Ito, Yoshiaki
Takamisawa, Itaru
Yajima, Junji
Kimura, Takeshi
Kadota, Kazushige
Saito, Shigeru
author_sort Shishido, Koki
collection PubMed
description The aim of this study is to evaluate the long-term safety and efficacy of the 2.25 mm bioresorbable-polymer sirolimus-eluting Ultimaster stent in a Japanese patient population. Treatment of coronary artery disease in very small vessels is associated with an increased risk for cardiac events. The CENTURY JSV study is a prospective, multicenter, single-arm study. Seventy patients with stable and unstable coronary artery disease with a coronary lesion eligible for implantation with a 2.25 mm stent were enrolled in this study. Patients underwent clinical follow-up through 5-year after the PCI procedure. The mean age was 70.4 ± 9.2 years. The prevalence of diabetes mellitus was 37.1%, all not insulin dependent. The incidence of major adverse cardiac events, defined as cardiac death, target vessel myocardial infarction (MI), and clinically driven target lesion revascularization (CD-TLR) at 5 years was 5.7%. A non-Q wave MI was noted in 1.4% and 4.3% underwent a CD-TLR. There was no stent thrombosis during the entire follow-up period. No cardiac events were reported between 2 and 5 years. This is the first study to demonstrate safety and effectiveness for 5 years after treatment of very small coronary disease with 2.25 mm-diameter DES. Clinical trial registration: UMIN000012928
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spelling pubmed-100202982023-03-18 Five-year clinical outcomes of a 2.25 mm sirolimus-eluting stent in Japanese patients with very small coronary artery disease: final results of the CENTURY JSV study Shishido, Koki Ando, Kenji Ito, Yoshiaki Takamisawa, Itaru Yajima, Junji Kimura, Takeshi Kadota, Kazushige Saito, Shigeru Cardiovasc Interv Ther Original Article The aim of this study is to evaluate the long-term safety and efficacy of the 2.25 mm bioresorbable-polymer sirolimus-eluting Ultimaster stent in a Japanese patient population. Treatment of coronary artery disease in very small vessels is associated with an increased risk for cardiac events. The CENTURY JSV study is a prospective, multicenter, single-arm study. Seventy patients with stable and unstable coronary artery disease with a coronary lesion eligible for implantation with a 2.25 mm stent were enrolled in this study. Patients underwent clinical follow-up through 5-year after the PCI procedure. The mean age was 70.4 ± 9.2 years. The prevalence of diabetes mellitus was 37.1%, all not insulin dependent. The incidence of major adverse cardiac events, defined as cardiac death, target vessel myocardial infarction (MI), and clinically driven target lesion revascularization (CD-TLR) at 5 years was 5.7%. A non-Q wave MI was noted in 1.4% and 4.3% underwent a CD-TLR. There was no stent thrombosis during the entire follow-up period. No cardiac events were reported between 2 and 5 years. This is the first study to demonstrate safety and effectiveness for 5 years after treatment of very small coronary disease with 2.25 mm-diameter DES. Clinical trial registration: UMIN000012928 Springer Nature Singapore 2022-09-02 2023 /pmc/articles/PMC10020298/ /pubmed/36050624 http://dx.doi.org/10.1007/s12928-022-00890-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Shishido, Koki
Ando, Kenji
Ito, Yoshiaki
Takamisawa, Itaru
Yajima, Junji
Kimura, Takeshi
Kadota, Kazushige
Saito, Shigeru
Five-year clinical outcomes of a 2.25 mm sirolimus-eluting stent in Japanese patients with very small coronary artery disease: final results of the CENTURY JSV study
title Five-year clinical outcomes of a 2.25 mm sirolimus-eluting stent in Japanese patients with very small coronary artery disease: final results of the CENTURY JSV study
title_full Five-year clinical outcomes of a 2.25 mm sirolimus-eluting stent in Japanese patients with very small coronary artery disease: final results of the CENTURY JSV study
title_fullStr Five-year clinical outcomes of a 2.25 mm sirolimus-eluting stent in Japanese patients with very small coronary artery disease: final results of the CENTURY JSV study
title_full_unstemmed Five-year clinical outcomes of a 2.25 mm sirolimus-eluting stent in Japanese patients with very small coronary artery disease: final results of the CENTURY JSV study
title_short Five-year clinical outcomes of a 2.25 mm sirolimus-eluting stent in Japanese patients with very small coronary artery disease: final results of the CENTURY JSV study
title_sort five-year clinical outcomes of a 2.25 mm sirolimus-eluting stent in japanese patients with very small coronary artery disease: final results of the century jsv study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020298/
https://www.ncbi.nlm.nih.gov/pubmed/36050624
http://dx.doi.org/10.1007/s12928-022-00890-y
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